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  • RESEARCH BRIEFINGS

High-resolution structures of two phosphatase–inhibitor complexes

Progression into the final phase of the cell cycle is driven mainly by protein phosphorylation, although it also requires the inhibition of phosphatase proteins, such as the PP2A:B55 complex. The structures reveal how PP2A:B55 binds to two of its inhibitors.

This is a summary of: Padi, S. K. R. et al. Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19. Nature https://doi.org/10.1038/s41586-023-06870-3 (2023).

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doi: https://doi.org/10.1038/d41586-023-03833-6

Figure 1 is published under a CC BY 4.0 licence.

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