The safety of engineered T cells is improved through gated expression of two chimeric antigen receptors.
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References
Roybal, K.T. et al. Cell 164, 770–779 (2016).
Gross, G. & Eshhar, Z. Annu. Rev. Pharmacol. Toxicol. 56, 59–83 (2016).
Hinrichs, C.S. & Restifo, N.P. Nat. Biotechnol. 31, 999–1008 (2013).
Linette, G.P. et al. Blood 122, 863–871 (2013).
Maude, S.L. et al. N. Engl. J. Med. 371, 1507–1517 (2014).
Obenaus, M. et al. Nat. Biotechnol. 33, 402–407 (2015).
Blankenstein, T., Leisegang, M., Uckert, W. & Schreiber, H. Curr. Opin. Immunol. 33, 112–119 (2015).
Leisegang, M., Kammertoens, T., Uckert, W. & Blankenstein, T. J. Clin. Invest. 126, 854–858 (2016).
Wilkie, S. et al. J. Clin. Immunol. 32, 1059–1070 (2012).
Kloss, C.C., Condomines, M., Cartellieri, M., Bachmann, M. & Sadelain, M. Nat. Biotechnol. 31, 71–75 (2013).
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Blankenstein, T. Receptor combinations hone T-cell therapy. Nat Biotechnol 34, 389–391 (2016). https://doi.org/10.1038/nbt.3539
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DOI: https://doi.org/10.1038/nbt.3539
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