Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Efficient generation of transcriptomic profiles by random composite measurements

Cleary, B., Cong, L., Cheung, A., Lander, E.S. & Regev, A. Cell 171, 1424–1436.e18 (2017).

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

Duvallet, C., Gibbons, S.M., Gurry, T., Irizarry, R.A. & Alm, E.J. Nat. Commun. 8, 1784 (2017).

A synthetic, light-driven consortium of cyanobacteria and heterotrophic bacteria enables stable polyhydroxybutyrate production

Weiss, T.L., Young, E.J. & Ducat, D.C. Metab. Eng. 44, 236–245 (2017).

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Balachandran, V.P. et al. Nature 551, 512–516 (2017).

A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy

Łuksza, M. et al. Nature 551, 517–520 (2017).

A next generation connectivity map: L1000 platform and the first 1,000,000 profiles

Subramanian, A. et al. Cell 171, 1437–1452.e17 (2017).