Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Miniaturized neural system for chronic, local intracerebral drug delivery

Dagdeviren, C. et al. Sci. Transl. Med. 10, eaan2742 (2018).

Aging and neurodegeneration are associated with increased mutations in single human neurons

Lodato, M.A. et al. Science 359, 555–559 (2018).

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Yin, H. et al. Nat. Chem. Biol. doi:10.1038/nchembio.2559 (2018).

Unification of protein abundance datasets yields a quantitative Saccharomyces cerevisiae proteome

Ho, B., Baryshnikova, A. & Brown, G.W. Cell Syst. doi:10.1016/j.cels.2017.12.004 (2018).

Multiplexed gene synthesis in emulsions for exploring protein functional landscapes

Plesa, C., Sidore, A.M., Lubock, N.B., Zhang, D. & Kosuri, S. Science 359, 343–347 (2018).

Cloning of macaque monkeys by somatic cell nuclear transfer

Liu, Z. et al. Cell doi:10.1016/j.cell.2018.01.020 (2018).