Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window

Halperin, S.O. et al. Nature 10.1038/s41586-018-0384-8 (2018)

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk

Zhou, J. et al. Nat. Genet. 50, 1171–1179 (2018)

A single-cell atlas of in vivo mammalian chromatin accessibility

Cusanovich, D.A. et al. Cell 10.1016/j.cell.2018.06.052 (2018)

Deep profiling of mouse splenic architecture with CODEX multiplexed imaging

Goltsev, Y. et al. Cell 10.1016/j.cell.2018.07.010 (2018)

Reprogramming human T cell function and specificity with non-viral genome targeting

Roth, T.L. et al. Nature 559, 405–409 (2018)