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Live bacterial biotherapeutics in the clinic

An engineered probiotic designed to treat a metabolic disease enters clinical trials.

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Figure 1: Bacteriotherapy for human health.

References

  1. Isabella, V. et al. Nat. Biotechnol. 36, 857–864 (2018).

    Article  CAS  Google Scholar 

  2. Bermúdez-Humarán, L.G. et al. J. Immunol. 175, 7297–7302 (2005).

    Article  Google Scholar 

  3. Lagenaur, L.A. et al. Mucosal Immunol. 4, 648–657 (2011).

    Article  CAS  Google Scholar 

  4. Duan, F.F., Liu, J.H. & March, J.C. Diabetes 64, 1794–1803 (2015).

    Article  CAS  Google Scholar 

  5. Durrer, K.E., Allen, M.S. & Hunt von Herbing, I. PLoS One 12, e0176286 (2017).

    Article  Google Scholar 

  6. Whelan, R.A. et al. Mol. Ther. 22, 1730–1740 (2014).

    Article  CAS  Google Scholar 

  7. Chen, Z. et al. J. Clin. Invest. 124, 3391–3406 (2014).

    Article  CAS  Google Scholar 

  8. Plovier, H. et al. Nat. Med. 23, 107–113 (2017).

    Article  CAS  Google Scholar 

  9. Quévrain, E. et al. Gut 65, 415–425 (2016).

    Article  Google Scholar 

  10. Hamady, Z.Z. et al. Inflamm. Bowel Dis. 17, 1925–1935 (2011).

    Article  Google Scholar 

  11. Limaye, S.A. et al. Cancer 119, 4268–4276 (2013).

    Article  CAS  Google Scholar 

  12. Motta, J.P. et al. Sci. Transl. Med. 4, 158ra144 (2012).

    Article  Google Scholar 

  13. Bermúdez-Humarán, L.G. et al. Microb. Cell Fact. 14, 26 (2015).

    Article  Google Scholar 

Download references

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Correspondence to Philippe Langella.

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Bermúdez-Humarán, L., Langella, P. Live bacterial biotherapeutics in the clinic. Nat Biotechnol 36, 816–818 (2018). https://doi.org/10.1038/nbt.4248

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