A potential role for glycosphingolipids and lipid rafts in apical sorting was initially met with enthusiasm, but genetic analysis has since provided little support for it. A report now establishes that glycosphingolipids mediate apical sorting, and specifically help maintain apicobasal polarity in Caenorhabditis elegans.
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Hyenne, V., Labouesse, M. Making sense of glycosphingolipids in epithelial polarity. Nat Cell Biol 13, 1185–1187 (2011). https://doi.org/10.1038/ncb2350
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DOI: https://doi.org/10.1038/ncb2350
