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Retriever fetches integrins from endosomes

Nature Cell Biology volume 19, pages 1144–1146 (2017)Cite this article

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Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

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Figure 1: The comparative molecular composition of the retromer (left) and the newly discovered heterotrimeric complex retriever (right).

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Acknowledgements

Thanks to A. M. Escobar and W. van Leeuwen for critically reading the manuscript.

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Authors and Affiliations

  1. Hubrecht Institute/KNAW and UMC Utrecht, Uppsalalaan 8, Utrecht, 3584 CT, The Netherlands

    Catherine Rabouille

  2. Department of Cell Biology, UMC Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Catherine Rabouille

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  1. Catherine Rabouille
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Correspondence to Catherine Rabouille.

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Rabouille, C. Retriever fetches integrins from endosomes. Nat Cell Biol 19, 1144–1146 (2017). https://doi.org/10.1038/ncb3612

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