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Myofibrils put the squeeze on nuclei

Nature Cell Biology volume 19, pages 1148–1150 (2017)Cite this article

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During muscle development, nuclei travel from the centre of the myofibre to the periphery, a process defective in certain diseases. A new study reveals that this movement is due to centripetal forces imposed on nuclei by the crosslinking and contraction of myofibrils.

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Figure 1: Myonuclear movement during muscle development.
Figure 2: Myofibril zipping causes myonuclear extrusion to the periphery.

References

  1. Romero, N. B. Neuromusc. Dis. 20, 223–228 (2010).

    Article  Google Scholar 

  2. Metzger, T. et al. Nature 484, 120–124 (2012).

    Article  CAS  Google Scholar 

  3. Roman, W. et al. Nat. Cell Biol. 19, 1189–1201 (2017).

    Article  CAS  Google Scholar 

  4. Cadot, B., Gache, V. & Gomes, E. R. Nucleus 6, 373–381 (2015).

    Article  Google Scholar 

  5. Cadot, B. et al. Nat. Publ. Gr. 13, 741–749 (2012).

    CAS  Google Scholar 

  6. Falcone, S. et al. EMBO Mol. Med. 6, 1455–1475 (2014).

    Article  CAS  Google Scholar 

  7. Folker, E. S., Schulman, V. K. & Baylies, M. K. Development 139, 3827–3837 (2012).

    Article  CAS  Google Scholar 

  8. Schulman, V. K., Folker, E. S., Rosen, J. N. & Baylies, M. K. PLoS Genet. 10, e100880 (2014).

    Article  Google Scholar 

  9. Zhang, J. et al. Hum. Mol. Genet. 19, 329–341 (2009).

    Article  Google Scholar 

  10. Elhanany-Tamir, H. et al. J. Cell Biol. 198, 833–846 (2012).

    Article  CAS  Google Scholar 

  11. Jungbluth, H. & Gautel, M. Front. Aging Neurosci. 6, 339 (2014).

    Article  Google Scholar 

  12. Ottenheijm, C. A. C. et al. J. Struct. Biol. 170, 334–343 (2010).

    Article  CAS  Google Scholar 

  13. Davidson, P. M. & Lammerding, J. B. Trends Cell Biol. 24, 247–256 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

J.N.R. and M.K.B. are supported by the NIH (GM078318, AR108981) to M.K.B. and National Cancer Institute (P30 CA 008748) core grant to Memorial Sloan Kettering Cancer Center.

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  1. Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA

    Jonathan N. Rosen & Mary K. Baylies

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  1. Jonathan N. Rosen
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  2. Mary K. Baylies
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Correspondence to Mary K. Baylies.

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The authors declare no competing financial interests.

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Rosen, J., Baylies, M. Myofibrils put the squeeze on nuclei. Nat Cell Biol 19, 1148–1150 (2017). https://doi.org/10.1038/ncb3618

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