The cytokine tumour necrosis factor (TNF) and the toll-like receptors (TLRs) coordinate immune responses by activating inflammatory transcriptional programs, but these signals can also trigger cell death. Recent studies identify the MAP kinase substrate MK2 as a key player in determining whether cells live or die in response to TNF and TLR signalling.
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References
Newton, K. & Dixit, V. M. Cold Spring Harb. Perspect. Biol. 4, a006049 (2012).
Silke, J., Rickard, J. A. and Gerlic, M. Nat. Immunol. 16, 689–697 (2015).
Menon, M. B. et al. Nat. Cell Biol. 19, 1248–1259 (2017).
Dondelinger, Y. et al. Nat. Cell Biol. 19, 1237–1247 (2017).
Jaco, I. et al. Mol. Cell 66, 698–710 (2017).
Gaestel, M. Nat. Rev. Mol. Cell Biol. 7, 120–130 (2006).
Dondelinger, Y. et al. Mol. Cell 60, 63–76 (2015).
Oberst, A. & Green, D. R. Nat. Rev. Mol. Cell Biol. 12, 757–763 (2011).
Dix, M. M. et al. Cell 150, 426–440 (2012).
Peterson, L. W. J. Exp. Med. http://doi.org/ccs9 (2017).
Cullen, S. P., Henry, C. M., Kearney, C. J. & Logue, S. E. Mol. Cell 49, 1034–1048 (2013).
Yatim, N. et al. Science 350, 328–334 (2015).
Philip, N. H. et al. Proc. Natl Acad. Sci. USA 111, 7385–7390 (2014).
Varfolomeev, E. Cell 131, 669–681 (2007).
Lalaoui, N. et al. Cancer Cell 30, 499–500 (2016).
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Oberst, A. MK2 balances inflammation and cell death. Nat Cell Biol 19, 1150–1152 (2017). https://doi.org/10.1038/ncb3619
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DOI: https://doi.org/10.1038/ncb3619
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