Crystal structure and drug pharmacophore structure-activity data guided a combined mutagenesis and chemical screen to develop ligand-gated ion channels activated by unique chemical agonists. Through genetic engineering, these channels can be used to manipulate neuronal excitability and dissect the neuronal circuitry responsible for complex behaviors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Magnus, C.J. et al. Science 333, 1292–1296 (2011)10.1126/science.1206606.
Thompson, A.J., Lester, H.A. & Lummis, S.C. Q. Rev. Biophys. 43, 449–499 (2010)10.1017/S0033583510000168.
Hibbs, R.E. & Gouaux, E. Nature 474, 54–60 (2011)10.1038/nature10139.
Eiselé, J.L. et al. Nature 366, 479–483 (1993)10.1038/366479a0.
Jansen, M., Bali, M. & Akabas, M.H. J. Gen. Physiol. 131, 137–146 (2008)10.1085/jgp.200709896.
Goyal, R., Salahudeen, A.A. & Jansen, M. J. Biol. Chem. published online, 10.1074/jbc.M111.269647 (15 August 2011).
Celie, P.H. et al. Neuron 41, 907–914 (2004)10.1016/S0896-6273(04)00115-1.
Bodnar, A.L. et al. J. Med. Chem. 48, 905–908 (2005)10.1021/jm049363q.
Betley, J.N. & Sternson, S.M. Hum. Gene Ther. 22, 669–677 (2011)10.1089/hum.2010.204.
Unwin, N. J. Mol. Biol. 346, 967–989 (2005)10.1016/j.jmb.2004.12.031.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Akabas, M. Manipulating the munchies in mice. Nat Chem Biol 7, 759–760 (2011). https://doi.org/10.1038/nchembio.697
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.697