Characterization of the mutational landscape of tumors is important to understanding disease etiology but does not provide mechanistic insight into the functional role of specific mutations. A new study introduces a statistical mechanical framework that draws on biophysical data from SH2 domain–phosphoprotein interactions to predict the functional effects of mutations in cancer.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Understanding cancer complexome using networks, spectral graph theory and multilayer framework
Scientific Reports Open Access 03 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Nigro, J.M. et al. Nature 342, 705–708 (1989).
Freed-Pastor, W.A. et al. Cell 148, 244–258 (2012).
AlQuraishi, M., Koytiger, G., Jenney, A., MacBeath, G. & Sorger, P.K. Nat. Genet. 46, 1363–1371 (2014).
Zhang, B. et al. Cell 153, 707–720 (2013).
Chen, J.C. et al. Cell 159, 402–414 (2014).
Zhong, Q. et al. Mol. Syst. Biol. 5, 321 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Califano, A. Predicting protein networks in cancer. Nat Genet 46, 1252–1253 (2014). https://doi.org/10.1038/ng.3156
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3156
This article is cited by
-
Understanding cancer complexome using networks, spectral graph theory and multilayer framework
Scientific Reports (2017)