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Killer T cells with a beta-flavi(r) for dengue

Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.

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Figure 1: TRBV11.2+ CD8+ T cell populations of weak to moderate affinity expand during sequential infection with heterologous DENV serotypes.

References

  1. Guzman, M.G., Alvarez, M. & Halstead, S.B. Arch. Virol. 158, 1445–1459 (2013).

    Article  CAS  Google Scholar 

  2. Screaton, G., Mongkolsapaya, J., Yacoub, S. & Roberts, C. Nat. Rev. Immunol. 15, 745–759 (2015).

    Article  CAS  Google Scholar 

  3. Culshaw, A. et al. Nat. Immunol. 18, 1228–1237 (2017).

    Article  CAS  Google Scholar 

  4. Davenport, F.M., Hennessy, A.V. & Francis, T. Jr. J. Exp. Med. 98, 641–656 (1953).

    Article  CAS  Google Scholar 

  5. Klenerman, P. & Zinkernagel, R.M. Nature 394, 482–485 (1998).

    Article  CAS  Google Scholar 

  6. Mongkolsapaya, J. et al. Nat. Med. 9, 921–927 (2003).

    Article  CAS  Google Scholar 

  7. Duangchinda, T. et al. Proc. Natl. Acad. Sci. USA 107, 16922–16927 (2010).

    Article  CAS  Google Scholar 

  8. Weiskopf, D. et al. Proc. Natl. Acad. Sci. USA 110, E2046–E2053 (2013).

    Article  CAS  Google Scholar 

  9. Nivarthi, U.K. et al. J. Immunol. 193, 5402–5413 (2014).

    Article  CAS  Google Scholar 

  10. Jenkins, M.K., Chu, H.H., McLachlan, J.B. & Moon, J.J. Annu. Rev. Immunol. 28, 275–294 (2010).

    Article  CAS  Google Scholar 

  11. Hogquist, K.A. & Jameson, S.C. Nat. Immunol. 15, 815–823 (2014).

    Article  CAS  Google Scholar 

  12. Andrade, D.V. & Harris, E. Virus Res. http://dx.doi.org/10.1016/j.virusres.2017.06.019 (2017).

Download references

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Correspondence to Sydney Blevins or Eric S Huseby.

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Blevins, S., Huseby, E. Killer T cells with a beta-flavi(r) for dengue. Nat Immunol 18, 1186–1188 (2017). https://doi.org/10.1038/ni.3833

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