Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.
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Blevins, S., Huseby, E. Killer T cells with a beta-flavi(r) for dengue. Nat Immunol 18, 1186–1188 (2017). https://doi.org/10.1038/ni.3833
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DOI: https://doi.org/10.1038/ni.3833