Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cytokine-driven role of Srebps in killer cell metabolism

Nature Immunology volume 18, pages 1183–1184 (2017)Cite this article

Subjects

A new and unexpected role is identified for Srebps in controlling NK cell activity that is independent of their role in lipid biosynthesis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Killer cell metabolism.

Kim Caesar/Springer Nature

References

  1. Pearce, E.L., Poffenberger, M.C., Chang, C.H. & Jones, R.G. Science 342, 1242454 (2013).

    PubMed  PubMed Central  Google Scholar 

  2. Kidani, Y. et al. Nat. Immunol. 14, 489–499 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shimano, H. & Sato, R. Nat. Rev. Endocrinol. http://dx.doi.org/10.1038/nrendo.2017.91 (29 August 2017).

  4. Assmann, N. et al. Nat. Immunol. 18, 1197–1206 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. Vivier, E. et al. Science 331, 44–49 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Guillerey, C., Huntington, N.D. & Smyth, M.J. Nat. Immunol. 17, 1025–1036 (2016).

    Article  CAS  PubMed  Google Scholar 

  7. Donnelly, R.P. et al. J. Immunol. 193, 4477–4484 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Marçais, A. et al. Nat. Immunol. 15, 749–757 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chang, S. & Aune, T.M. Proc. Natl. Acad. Sci. USA 102, 17095–17100 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Gardiner, C.M. & Finlay, D.K. Front. Immunol. 8, 367 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  11. York, A.G. & Bensinger, S.J. J. Exp. Med. 210, 1653–1656 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Gold, E.S. et al. Proc. Natl. Acad. Sci. USA 111, 10666–10671 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Viel, S. et al. Sci. Signal. 9, ra19 (2016).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Immunology of Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Australia, Queensland

    Camille Guillerey & Mark J Smyth

Authors
  1. Camille Guillerey
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark J Smyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark J Smyth.

Ethics declarations

Competing interests

M.J.S. has research agreements with Bristol Myers Squibb, Tizona Therapeutics, Corvus Pharmaceuticals and Aduro Biotech.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guillerey, C., Smyth, M. Cytokine-driven role of Srebps in killer cell metabolism. Nat Immunol 18, 1183–1184 (2017). https://doi.org/10.1038/ni.3855

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3855

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing