Two recent studies show that 'silent' variants can modulate regulatory circuits, including those in noncoding RNAs, affecting cancer predisposition and drug sensitivity.
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Acknowledgements
M.H. and I.R. are supported by the European Research Council Starting Grant 281877 and the Spanish Ministry of Science Grant BFU2014-58027-R.
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Raimondi, I., Huarte, M. Noncoding RNAs as effective markers in cancer-care management. Nat Med 23, 1122–1123 (2017). https://doi.org/10.1038/nm.4423
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DOI: https://doi.org/10.1038/nm.4423