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Engineering MeCP2 to spy on its targets

A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice.

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Figure 1: A new mouse model for the role of MeCP2 in Rett syndrome.

Katie Vicari/Springer Nature

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Correspondence to Lisa M Monteggia.

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Horvath, P., Monteggia, L. Engineering MeCP2 to spy on its targets. Nat Med 23, 1120–1122 (2017). https://doi.org/10.1038/nm.4425

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