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An immunosuppressive pathway for tumor progression

An active immunosuppressive pathway is identified in colon cancer that confers immune evasion by the cancer and can be targeted to synergize with immunotherapies.

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Figure 1: A targetable immunosuppressive pathway promoting tumor progression.

Marina Corral Spence/Springer Nature

References

  1. Dyck, L. & Mills, K.H.G. Eur. J. Immunol. 47, 765–779 (2017).

    Article  CAS  Google Scholar 

  2. Toh, J.W.T. et al. Clin. Colorectal Cancer 15, 285–291 (2016).

    Article  Google Scholar 

  3. Pitt, J.M. et al. Immunity 44, 1255–1269 (2016).

    Article  CAS  Google Scholar 

  4. Xiao, Q. et al. Nat. Med. 24, 262–270 (2018).

    Article  CAS  Google Scholar 

  5. Nusse, R. & Clevers, H. Cell 169, 985–999 (2017).

    Article  CAS  Google Scholar 

  6. Malladi, S. et al. Cell 165, 45–60 (2016).

    Article  CAS  Google Scholar 

  7. D'Amico, L. et al. J. Exp. Med. 213, 827–840 (2016).

    Article  CAS  Google Scholar 

  8. Patsoukis, N., Li, L., Sari, D., Petkova, V. & Boussiotis, V.A. Mol. Cell. Biol. 33, 3091–3098 (2013).

    Article  CAS  Google Scholar 

  9. Marçais, A. et al. Nat. Immunol. 15, 749–757 (2014).

    Article  Google Scholar 

  10. Cichocki, F. et al. Cancer Res. 77, 5664–5675 (2017).

    Article  CAS  Google Scholar 

  11. McCubrey, J.A. et al. Oncotarget 5, 2881–2911 (2014).

    Article  Google Scholar 

Download references

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Correspondence to Thierry Walzer.

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Marçais, A., Walzer, T. An immunosuppressive pathway for tumor progression. Nat Med 24, 260–261 (2018). https://doi.org/10.1038/nm.4508

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