The noncoding RNA LINP1 acts as a scaffold that links Ku and DNA-PKcs and enables efficient DNA double-strand-break repair through nonhomologous end joining (NHEJ), thereby enhancing the resistance of triple-negative breast cancer cells to radiation and chemotherapies.
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Lees-Miller, S., Beattie, T. & Tainer, J. Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer. Nat Struct Mol Biol 23, 509–510 (2016). https://doi.org/10.1038/nsmb.3240
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DOI: https://doi.org/10.1038/nsmb.3240
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