Abstract
The polymerization reactions of L-alanylglycine with diphenylphosphoryl azide (DPPA) were investigated under various reaction conditions. Dimethyl sulfoxide and triethylamine were found to be the most suitable solvent and base, respectively, for this polymerization reaction. A reaction time of two days at room temperature, employing 1.3 equivalent moles of DPPA and 2.6 equivalent moles of triethylamine corresponding to the amount of L-alanylglycine were considered to be the most appropriate reaction condition. In this case, poly(L-alanylglycine) which has the intrinsic viscosity of 0.16 in dichloroacetic acid at 25°C was obtained in 43% yield. Its infrared absorption spectrum and elemental analysis, and the amino acid analysis or the optical rotation for the acid hydrolysate indicated the high purity of poly(L-alanylglycine) obtained by this DPPA method.
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Nakajima, Bi., Nishi, N. Polymerization of L-Alanylglycine with Diphenylphosphoryl Azide. Polym J 13, 183–189 (1981). https://doi.org/10.1295/polymj.13.183
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DOI: https://doi.org/10.1295/polymj.13.183