Abstract
To investigate local interactions in tripeptide sequences composed of amino acids having aromatic side chains, conformational analysis of N-acetyl-N′-methylamide of the Phe-Phe-Phe tripeptide was theoretically carried out using the conformational energy-minimization procedure. The calculated results show that extended conformations are favorable conformations and β-bend and α-helical conformations are unstable ones for the Phe-Phe-Phe sequence. These results accord with the previous results that extended conformation of the Tyr21-Phe22-Tyr23 sequence in BPTI is stabilized by short-range interaction and also that the tripeptide sequence composed of Phe and Tyr residues found in other proteins also have a tendency to take extended conformations. Experimental results on oligopeptides composed of the Phe residue in the solid state and solutions also support our calculated results. It was also shown that inter-residue interactions indicate minor effects on the mean-square end-to-end distance of a tripeptide.
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Oka, M., Baba, Y., Kagemoto, A. et al. Theoretical Analysis of the Conformational Preference of the Phe-Phe-Phe Tripeptide Sequence. Polym J 21, 1011–1017 (1989). https://doi.org/10.1295/polymj.21.1011
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DOI: https://doi.org/10.1295/polymj.21.1011
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