Abstract
A number of glycopeptides were synthesized and investigated on their interactions with lipid bilayer membranes. Glycopeptides in which N-acetylglucosamine and a tripeptide are connected by aliphatic chains of different lengths were distributed to liposomes and influenced the structure of lipid bilayer membrane upon crosslinking by lection. However, the tripeptide chain was too short to penetrate the lipid membrane to form an ion channel across the membrane. Next, glycopeptides in which maltose is connected to α-helical polyalanines (DP 15 and 25) were synthesized. However, distribution of these glycopeptides to lipid bilayer membrane was very low. Finally, synthetic glycopeptides, Boc-(Ala-Aib)n-Lac, were distributed and oriented perpendicularly to the plane of lipid bilayer membrane. It was found that the glycopeptide with n=4 formed an aggregate in the membrane to form an ion channel upon interaction with lectin.
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Imanishi, Y., Kimura, S. Lipid Bilayer Membranes Containing Glycopeptides as Receptor Model. Polym J 23, 593–601 (1991). https://doi.org/10.1295/polymj.23.593
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DOI: https://doi.org/10.1295/polymj.23.593