Abstract
Gastrointestinal absorption behavior of [14C]poly(ethylene glycol) (PEG) 4000 was studied by mice. The absorption of the polymer 1 h after the oral administration was 2%-dose, though its appearance in the urine and the blood is few. On the other hand, the injection of the PEG into the duodenal ligated loop under anesthesia resulted in as high as 15%-dose absorption/h. Intraduodenal administration study revealed that the long retention of the polymer in the upper regions in the small intestines is necessary to its high absorption, and the poor absorption of the PEG seen after the oral administration seems to be brought about by its rapid transit and short retention in the upper intestines.
Similar content being viewed by others
Article PDF
References
M. D. Donovan, G. L. Flynn, and G. L. Amidon, Pharm. Res., 7, 863 (1990).
P. G. Jackson, M. H. Lessof, R. W. R. Baker, J. Ferrett, and D. M. MacDonald, Lancet, 1285 (1981).
D. J. Larwood and F. C. Szoka, J. Labelled Compounds and Radiopharm., 21, 603 (1984).
H. Yoshikawa, K. Takada, and S. Muranishi, J. Pharmaco-Dyn., 7, 1 (1984).
T. Yamamoto, Arch. Histol. Jpn., 45, 1 (1982).
K. Morimoto, T. Iwamoto, and K. Morisaka, J. Pharmaco-Dyn., 10, 85 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Koyama, Y., Tateishi, M., Kawaide, A. et al. Gastrointestinal Absorption of [14C]Poly(ethylene glycol) 4000. Polym J 24, 583–589 (1992). https://doi.org/10.1295/polymj.24.583
Issue Date:
DOI: https://doi.org/10.1295/polymj.24.583