Abstract
New biodegradable and biocompatible polyphosphate based on L-Tyr–L-Tyr or L-Ser–L-Tyr dipeptide as the recurring units were synthesized. One of these polyphosphates was chosen for the study of adjuvanticity in conjunction with the soluble antigen extracted from adult Schistosoma japonicum (SjAg). The preliminary results show that, when measuring the serum antibody response to SjAg in female mice over 10 weeks, the polyphosphate (I) exhibited strong adjuvant activity.
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Mao, HQ., Zhuo, RX. & Fan, CL. Synthesis and Biological Properties of Polymer Immunoadjuvants. Polym J 25, 499–505 (1993). https://doi.org/10.1295/polymj.25.499
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DOI: https://doi.org/10.1295/polymj.25.499