Abstract
Microsphere, poly(MAHP-co-MMA), was prepared by the emulsifier free emulsion copolymerization of 2-[2-(methacryloyloxy)ethyldimethylammonio]ethyl-6-[4-(4-methoxyphenylazo)phenoxy]hexyloxyphosphate (MAHP) and methyl methacrylate (MMA). The diameter of poly (MAHP-co-MMA) estimated from TEM varied from 234 to 402 nm, depending on the mol-% of MAHP to MMA in feed from f=0 to f=0.5. From XPS measurements of poly (MAHP-co-MMA) the polar head groups of MAHP were found to be located on the surface of particles. The adsorption of bovine serum albumin (BSA) onto poly(methyl methacrylate) [poly(MMA)] and poly(MAHP-co-MMA) microspheres were examined at pH 5.6. The introduction of phosphatidylcholine analog into poly(MMA) results in a drastic decrease in BSA adsorption. A controlled decrease in BSA adsorption was also observed in poly(MAHP-co-MMA) with cis-azobenzene moieties caused by UV irradiation.
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Sugiyama, K., Shiraishi, K., Ohga, K. et al. Synthesis of Poly(methyl methacrylate) Microspheres Bearing Phosphatidylcholine Analogous and Azobenzene Moieties. Polym J 25, 521–527 (1993). https://doi.org/10.1295/polymj.25.521
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DOI: https://doi.org/10.1295/polymj.25.521