Abstract
Several kinds of submicron-sized microspheres having environment-sensitive shells were prepared and the effect of shell structure on the properties of microspheres was studied. The shell was composed of crosslinked or hairy poly(N-isopropyl acrylamide) (PNIPAM) whose lower critical solution temperature was about 32°C but depended on the architecture of the shell. The resposivity of the shell to the change in environmental condition was sluggish when the shell was crosslinked. The decrease in the crosslink density of the shell was slightly effective in sharpening the response. But even non-crosslinked, hairy PNIPAM shell did not exhibit discontinuous transition at the critical condition. The response of hairy PNIPAM shell to environmental change was drastically sharpened by incorporating a slight amount of acrylic acid (AAc) in the hair.
Similar content being viewed by others
Article PDF
References
H. Kawaguchi, Functions of monodisperse, thermosensitive hydrogel microspheres. in “Biomedical Functions & Biotechnology of Natural and Artificial Polymers” Yalpani, M. Ed., ATL Press, Mount Prospect, IL, (1996) pp. 157-168.
H. Kawaguchi, K. Fujimoto, and Y. Mizuhara, Colloid Polym. Sci., 270, 53 (1992).
T. Kato, K. Fujimoto, and H. Kawaguchi, Polymer Gels Networks, 4, 307 (1994).
Y. Ohshima, K. Makino, T. Kato, K. Fujimoto, and H. Kawaguchi, J. Colloid Interface Sci., 159, 512 (1993).
K. Fujimoto, Y. Nakajima, and H. Kawaguchi, Polym. Intl., 30, 237 (1993).
H. Matsuoka, K. Fujimoto, and H. Kawaguchi, Polymer Gels Networks, 6, 319 (1998).
H. M. Crowther and B. Vincent, Colloid Polym. Sci., 276, 46 (1998).
P. W. Zhu and D. H. Napper, J. Colloid Interface Sci., 164, 489 (1994).
S. Hirotsu, Y. Hirokawa, and T. Tanaka, J. Chem. Phys., 87, 1329 (1987).
Y. Yoshida, K. Uchida, Y. Kaneko, K. Sakai, A. Kikuchi, Y. Sakurai, and T. Okano, Nature, 374, 240 (1995).
P. W. Zhu and D. H. Napper, Chem. Phys. Lett., 256, 51 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matsuoka, H., Fujimoto, K. & Kawaguchi, H. Stimuli-Response of Microsphere Having Poly(N-isopropylacrylamide) Shell. Polym J 31, 1139–1144 (1999). https://doi.org/10.1295/polymj.31.1139
Issue Date:
DOI: https://doi.org/10.1295/polymj.31.1139
Keywords
This article is cited by
-
Laterally sandwich-typed hydrogel columns with liner poly(N-isopropylacrylamide) layer: Preparation, swelling/deswelling kinetics and drug delivery characteristics
Journal of Wuhan University of Technology-Mater. Sci. Ed. (2012)
-
Effect of mixed solvent on fabrication, morphology and monodispersity of microspheres with hydrophobic poly(butyl methacrylate) shells
Journal of Wuhan University of Technology-Mater. Sci. Ed. (2012)
-
Poly(N-isopropylacrylamide)-based vertically sandwichtyped hydrogel with fast temperature-response speed and its controlled-release characteristics
Journal of Wuhan University of Technology-Mater. Sci. Ed. (2012)
-
Preparation of pH-sensitive hydrogel microspheres of poly(acrylamide-co-methacrylic acid) with sharp pH–volume transition
Colloid and Polymer Science (2007)
-
Characteristics of pH-sensitive hydrogel microsphere of poly(acrylamide-co-methacrylic acid) with sharp pH–volume transition
Colloid and Polymer Science (2007)