Abstract
The present study deals with preparation and swelling properties of micrometer-sized poly(N-isopropylacrylamide) (PNIPAM) hydrogel particles. Aqueous precipitation polymerization of NIPAM with N,N′-methylenebisacrylamide (MBAAm) was performed with varying electrolyte concentrations in the polymerization media. Sodium chloride was used as an electrolyte. According to the particle size analysis by transmission electron microscope, the particle size increased in the range of 0.55 to 1.60 µm with an increase in the electrolyte concentration up to 1.6 wt %. The concentration is based on the NIPAM monomer weight. Dynamic light scattering data showed that swelling ratio of PNIPAM hydrogel particles in water varied from 10 to 40 as the electrolyte concentration at particle preparation increased from 0 to 1.6 wt %. Time-course analysis of particle size showed that an increase in particle size would be caused by aggregation of smaller particles. In conclusion, micrometer-sized PNIPAM particles with high swelling capacity can be obtained by the addition of an electrolyte in polymerization media.
Similar content being viewed by others
Article PDF
References
R. H. Pelton, Adv. Colloid Interface Sci., 85, 1 (2000).
H. Kawaguchi, in “Biomedical Functions and Biotechnology of Natural and Artificial Polymers,” M. Yalpani, Ed., ATL Press, 1996, p 157.
K. Fujimoto, Y. Nakajima, M. Kashiwabara, and H. Kawaguchi, Polym. Int., 30, 237 (1993).
H. Matsuoka, K. Fujimoto, and H. Kawaguchi, Polym. J., 31, 1139 (1999).
K. Makino, S. Yamamoto, K. Fujimoto, H. Kawaguchi, and H. Ohshima, J. Colloid Interface Sci., 166, 251 (1994).
M. Rasmusson, B. Vincent, and N. Marston, Colloid Polym. Sci., 278, 253 (2000).
S. Takeuchi, M. Oike, C. Kowitz, C. Shimasaki, K. Hasegawa, and H. Kitano, Makromol. Chem., 194, 551 (1993).
D. Duracher, F. Sauzedde, A. Elaissari, C. Pichot, and L. Nabzar, Colloid Polym. Sci., 276, 920 (1998).
H. Senff, W. Richtering, Ch. Norhausen, A. Weiss, and M. Ballauff, Langmuir, 15, 102 (1999).
H. Senff and W. Richtering, J. Chem. Phys., 111, 1705 (1999).
W. Leobandung, H. Ichikawa, Y. Fukumori, and N. A. Peppas, J. Controlled Release, 80, 357 (2002).
M. J. Serpe, K. A. Yarmey, C. M. Nolan, and L. A. Lyon, Biomacromolecules, 6, 408 (2005).
T. Shiroya, N. Tamura, M. Yasui, K. Fujimoto, and H. Kawaguchi, Colloids Surf., B, 4, 267 (1995).
M. Yasui, T. Shiroya, K. Fujimoto, and H. Kawaguchi . Colloids Surf., B, 8, 311 (1997).
J. M. Weissman, H. B. Sunkara, A. S. Tse, and S. A. Asher, Science, 274, 959 (1996).
J. Kim, M. J. Serpe, and L. A. Lyon, Angew. Chem., Int. Ed., 44,1333 (2005).
A. Kondo, H. Kamura, and K. Higashitani, Appl. Microbiol. Biotechnol., 41, 99 (1994).
R. H. Pelton and P. Chibante, Colloids Surf., 20, 247 (1986).
W. McPhee, K. C. Tam, and R. H. Pelton, J. Colloid Interface Sci. 156, 24 (1993).
C. Yi, Z. Deng, and Z. Xu, Colloids Polym. Sci., 283, 1259 (2005).
C. Jones and L. W. Lyon, Macromolecules, 33, 8301 (2000).
M. Q. Chen, T. Serizawa, M. Li, and M. Akashi, Polym. J., 35, 901 (2003).
P. J. Dowding, B. Vincent, and E. Williams, J. Colloid Interface Sci., 221, 268 (2000).
H. Shimizu, T. Koshina, R. Wada, and M. Okabe, Trans. Mater. Res. Soc. Jpn., 31, 791 (2006).
H. Shimizu, R. Wada, and M. Okabe, Kobunshi Ronbunshu, 65, 751 (2008).
S. Fujishige, K. Kubota, and I. Ando, J. Phys. Chem., 93, 3311 (1989).
H. G. Schilda and D. A. Tirrell, Langmuir, 7, 1319 (1991).
Z. F. M. Said, Polym. Int., 35, 379 (1994).
T. Tanrisever, O. Okay, and I. C. Sonmezoglu, J. Appl. Polym. Sci., 61, 485 (1996).
M. Miyaki, K. Fujimoto, and H. Kawaguchi, Colloids Surf., A, 153, 603 (1999).
S. Can and T. Tanrisever, J. Appl. Polym. Sci., 103, 2494 (2007).
R. Pelton, Macromol. Symp., 207, 57 (2004).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shimizu, H., Wada, R. & Okabe, M. Preparation and Characterization of Micrometer-Sized Poly(N-isopropylacrylamide) Hydrogel Particles. Polym J 41, 771–777 (2009). https://doi.org/10.1295/polymj.PJ2009039
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1295/polymj.PJ2009039
Keywords
This article is cited by
-
Diffusion of rigid nanoparticles in crowded polymer-network hydrogels: dominance of segmental density over crosslinking density
Colloid and Polymer Science (2017)