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Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study

Journal of Human Hypertension volume 34, pages 125–131 (2020)Cite this article

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Abstract

The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5–24.9) aged 35–69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53–5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT.

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Funding

This study was supported by Grants-in-Aid for Scientific Research on Priority Areas of Cancer (No. 17015018) and Innovative Areas (No. 221S0001) and by a JSPS KAKENHI Grant (No. 16H06277) from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

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Authors and Affiliations

  1. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Rieko Okada, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Sayo Kawai, Takashi Tamura, Asahi Hishida, Mariko Naito & Kenji Wakai

  2. Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan

    Tae Sasakabe & Sayo Kawai

  3. Department of Environmental Medicine and Infectious Disease, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hiroaki Ikezaki & Norihiro Furusyo

  4. Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan

    Keitaro Tanaka & Megumi Hara

  5. Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

    Sadao Suzuki & Miki Watanabe

  6. Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Toshiro Takezaki

  7. School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    Daisaku Nishimoto

  8. Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Daisuke Matsui & Isao Watanabe

  9. Laboratory of Public Health, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan

    Kiyonori Kuriki

  10. Department of Health Science, Shiga University of Medical Science, Otsu, Japan

    Naoyuki Takashima

  11. Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Otsu, Japan

    Yasuyuki Nakamura

  12. Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan

    Sakurako Katsuura-Kamano & Kokichi Arisawa

  13. Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan

    Haruo Mikami & Yoko Nakamura

  14. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

    Isao Oze

  15. Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan

    Yuriko N. Koyanagi

  16. Department of Oral Epidemiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

    Mariko Naito

Authors
  1. Rieko Okada
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  2. Yuka Kadomatsu
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  3. Mineko Tsukamoto
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  19. Naoyuki Takashima
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  20. Yasuyuki Nakamura
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  21. Sakurako Katsuura-Kamano
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  22. Kokichi Arisawa
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  23. Haruo Mikami
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  24. Yoko Nakamura
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  28. Kenji Wakai
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for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

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Correspondence to Rieko Okada.

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Okada, R., Kadomatsu, Y., Tsukamoto, M. et al. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. J Hum Hypertens 34, 125–131 (2020). https://doi.org/10.1038/s41371-019-0230-y

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