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Analysis of ambulatory blood pressure monitoring data in patients with ankylosing spondylitis without clinically evident cardiovascular disease

Journal of Human Hypertension volume 36, pages 531–536 (2022)Cite this article

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Abstract

Ankylosing spondylitis (AS) is associated with an increased risk of cardiovascular morbidity and mortality. Parameters, such as non-dipper, average real variability (ARV), pulse pressure index (PPI), and ambulatory arterial stiffness index (AASI) obtained from ambulatory blood pressure monitoring (ABPM), provide information about adverse cardiovascular outcomes. In this study, these indexes were evaluated in patients with AS. Sixty-five patients with AS and 65 control subjects were included in this study. Non-dipper pattern, ARV, PPI, and AASI parameters were assessed using 24-h ABPM recordings. Twenty-four-hour systolic, diastolic, mean standard deviation, PPI, ARV, and AASI were higher in patients with AS (p < 0.05 all parameters). Non-dipper (43.1% vs. 21.5%, p = 0.007) and reverse dipper (10.8% vs. 0%, p = 0.013) patterns were more common in patients with AS. In addition, disease duration was moderately correlated with AASI and ARV (r = 0.36, p = 0.003; r = 0.31, p = 0.012, respectively). This study showed that PPI, AASI, ARV, and dipper pattern were impaired in patients with AS evaluated with ABPM.

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Fig. 1: Relationships between disease duration and 24-h ABPM parameters.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine, Gazi University, Ankara, Turkey

    Mustafa Candemir, Emrullah Kiziltunç, Burcu Cihan & Asife Şahinarslan

  2. Department of Internal Medicine, Yozgat City Hospital, Yozgat, Turkey

    Burcu Candemir

  3. Department of Cardiology, Yozgat City Hospital, Yozgat, Turkey

    Serdar Nurkoç

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  1. Mustafa Candemir
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  2. Emrullah Kiziltunç
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  3. Burcu Candemir
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  4. Serdar Nurkoç
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  5. Burcu Cihan
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  6. Asife Şahinarslan
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Contributions

Concept: MC, BCandemir; design: MC, BCandemir, EK; supervision: MC, BCandemir, SN, AŞ; materials: MC, BCandemir, BCihan, SN; data collection and/or processing: MC, BCandemir, BCihan, SN; analysis and/or interpretation: MC, EK, BCihan; literature search: MC, BCandemir, AŞ; writing: MC, EK, AŞ; critical review: MC, AŞ.

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Correspondence to Mustafa Candemir.

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Candemir, M., Kiziltunç, E., Candemir, B. et al. Analysis of ambulatory blood pressure monitoring data in patients with ankylosing spondylitis without clinically evident cardiovascular disease. J Hum Hypertens 36, 531–536 (2022). https://doi.org/10.1038/s41371-021-00542-3

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  • DOI: https://doi.org/10.1038/s41371-021-00542-3

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