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Predictors of poor neonatal outcomes in prenatally diagnosed multicystic dysplastic kidney disease

Journal of Perinatology volume 38, pages 658–664 (2018)Cite this article

Subjects

Abstract

Objective

Multicystic dysplastic kidney (MCDK) is one of the most common anomalies detected by prenatal ultrasound. Our objective was to identify factors associated with severe adverse neonatal outcomes of prenatally diagnosed MCDK

Study design

A retrospective review of prenatally diagnosed MCDK (1 January 2009 to 30 December 2014) from a single academic center was conducted. The primary outcome was death or need for dialysis among live-born infants. Associations between prenatal characteristics and outcome were analyzed by Fisher’s exact test and Mann–Whitney test.

Results

A total of 53 cases of prenatally suspected MCDK were included, of which 46 cases were live-born and confirmed postnatally (38 survivors, 8 non-survivors). Prenatally diagnosed extrarenal anomalies, bilateral MCDK, contralateral renal anomalies, and anhydramnios were significantly associated with death or need for dialysis (all p < 0.0001).

Conclusions

Prenatally identified findings are associated with adverse neonatal outcome, and can guide counseling and management planning. In the absence of significant associated findings, prenatally diagnosed unilateral MCDK has a benign neonatal course.

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Acknowledgements

We thank the neonatal nurse practitioners at the Fetal and Pregnancy Health Program at Lucile Packard Children’s Hospital Stanford for entering data into the mother–fetus–baby-linked database.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, Stanford University School of Medicine, Stanford, CA, USA

    Malathi Balasundaram, Valerie Y. Chock & Susan R. Hintz

  2. Fetal and Pregnancy Health Program, Lucile Packard Children’s Hospital Stanford, Palo Alto, CA, USA

    Malathi Balasundaram, Valerie Y. Chock, Hsi Yang Wu, Yair J. Blumenfeld & Susan R. Hintz

  3. Division of Urology, Stanford University School of Medicine, Stanford, CA, USA

    Hsi Yang Wu

  4. Department of Obstetrics & Gynecology, Maternal Fetal Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Yair J. Blumenfeld

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  1. Malathi Balasundaram
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Correspondence to Malathi Balasundaram.

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Balasundaram, M., Chock, V.Y., Wu, H.Y. et al. Predictors of poor neonatal outcomes in prenatally diagnosed multicystic dysplastic kidney disease. J Perinatol 38, 658–664 (2018). https://doi.org/10.1038/s41372-018-0093-z

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  • DOI: https://doi.org/10.1038/s41372-018-0093-z

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