Correction to: Acta Pharmacologica Sinica https://doi.org/10.1038/s41401-020-00517-z; published online 24 September 2020

During our recent check of our published article entitled “α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice” published in Acta Pharmacologica Sinica. We realized that there were several mistakes in the final assemble of figures: (1) in Figs. 2a and 4a, representative images of Masson staining were obtained at 20× rather than 2×; (2) in Figs. 2g and 4g, representative images of echocardiography were mis-placed in the process of assembling figures; (3) in Fig. 8d, the chemokine determined is MIP-1α rather than MCP-1α. However, these mistakes do not affect the conclusions of the original article nor the text of the article and the figure legends. We apologize sincerely for any inconvenience caused.

Fig. 2: iNKT cells activated by αGC accelerate progressive ISO stimulation-induced cardiac fibrosis in mice.
figure 2

WT C57BL/6 mice received ISO (5 mg/kg per day) alone for 7 days or together with αGC (3 μg/mouse) every other day. a HE staining and Masson’s trichrome staining were performed, and the fibrotic area/LV percentage (b) and ratio of heart weight to body weight (c) were calculated. d, e, f Whole-heart lysates were subjected to immunoblotting with the indicated antibody. GAPDH was used as the loading control. The data are expressed as a ratio of the experimental value to the mean value of the saline group. g, h, i Echocardiography was performed to evaluate cardiac function. The data are expressed as the mean ± SD. *P < 0.05 and **P < 0.01.

Fig. 4: iNKT cells activated by OCH attenuate progressive ISO stimulation-induced cardiac fibrosis in mice.
figure 4

WT C57BL/6 mice received ISO (5 mg/kg per day) alone for 7 days or with OCH (3 μg/mouse) every other day. a HE staining and Masson’s trichrome staining were performed, and the fibrotic area/LV percentage (b) and ratio of heart weight to body weight (c) were calculated. d, e, f Whole-heart lysates were subjected to immunoblotting with the indicated antibody. GAPDH was used as the loading control. The data are expressed as a ratio of the experimental value to the mean value of the saline group. g, h, i Echocardiography was performed to evaluate cardiac function. The data are expressed as the mean ± SD. *P < 0.05 and **P < 0.01.

Fig. 8: Cardiac macrophages in αGC-induced cardiotoxicity.
figure 8

ad Hearts were harvested from mice stimulated with ISO (5 mg/kg per day) alone for 7 days or together with αGC or OCH every other day. a FACS was used to analyze the proportions of macrophages and adult monocyte-derived macrophages (infiltrated) in the hearts. b The percentage of CCR2-positive macrophages among CD11b+ F4/80+ cells was calculated. c, d Whole-heart lysates were subjected to ELISA immunoassays to determine the protein concentrations of MCP-1 and MIP-1α. The data are expressed as the mean ± SD. *P < 0.05 and **P < 0.01.

The corrected Figures are as follow: