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Cyclodextrin-based nanoparticles encapsulating α-mangostin and their drug release behavior: potential carriers of α-mangostin for cancer therapy

Polymer Journal volume 52, pages 457–466 (2020)Cite this article

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Abstract

α-Mangostin (MGS), an anti-cancer compound, is a xanthone derivative and is extracted from the pericarps of mangosteen. MGS exhibits a variety of bioactivities, such as antioxidant, cytotoxic, anti-inflammatory, and antibacterial effects, as well as anticancer activity. However, MGS has not been approved for clinical use because of its poor bioavailability. There have been many efforts to solve this problem by use of drug carriers. Cyclodextrins (CDs) are well known as nontoxic and biodegradable drug carriers and can encapsulate MGS. In this study, we prepared CD-based nanoparticles (CDNPs) by a polyaddition reaction using epichlorohydrin and characterized them by dynamic light scattering and static light scattering coupled with fractionation. The encapsulation of MGS into CDNPs was examined, and we found that the loading ratio of MGS for CDNPs is much higher than that for CDs themselves. The cytotoxicity of the CDNP/MGS complex was examined, indicating the potential of CDNP as a carrier of MGS.

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Acknowledgements

This work was supported by JST CREST Grant Number JPMJCR1521, Japan. This work was also supported by a JSPS Grant-in-Aid for Scientific Research (B) (Grant Number 17K14073).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Kitakyushu, 1-1 Hibikino, Kitakyushu, Fukuoka, 808-0135, Japan

    Van T. H. Doan, Ji Ha Lee, Rintaro Takahashi, Shota Fujii & Kazuo Sakurai

  2. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet road, Cau Giay, Hanoi, Vietnam

    Phuong T. M. Nguyen

  3. Key Laboratory of Enzyme and Protein Technology, VNU University of Science, Vietnam National University, 334 Nguyen Trai street, Thanh Xuan, Hanoi, Vietnam

    Van Anh T. Nguyen & Huong T. T. Pham

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  1. Van T. H. Doan
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Correspondence to Shota Fujii or Kazuo Sakurai.

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Doan, V.T.H., Lee, J.H., Takahashi, R. et al. Cyclodextrin-based nanoparticles encapsulating α-mangostin and their drug release behavior: potential carriers of α-mangostin for cancer therapy. Polym J 52, 457–466 (2020). https://doi.org/10.1038/s41428-019-0296-y

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