Correction to: The Journal of Antibiotics (1992) 45, 1553–1556. https://doi.org/10.7164/antibiotics.45.1553
The authors of the above article misjudged the structure determination of MCF (metacytofilin). Our recent analyses using X-ray crystallography and NMR techniques revealed the correct structure as shown in Figs. 1, 2, and 3. The structure of MCF was identified with diatretol [1].
Single-crystal X-ray data were collected on a Rigaku R-AXIS RAPID diffractometer using filtered Cu–Ka radiation. The crystal data are: empirical formula: C16H22N2O4, FW 306.36, crystal color: colorless, habit: platelet, crystal dimensions: 0.300 × 0.200 × 0.030 mm, crystal system: monoclinic, lattice type: primitive, lattice parameters: a = 6.06079 (14) Å, b = 17.1982 (4) Å, c = 9.1651 (2) Å, β = 108.523 (8)°, V = 905.83 (6) Å3, space group: P21, Z value: 2, D calc: 1.123 g/cm3, F 000: 328.00, µ (CuKa): 6.671 cm−1. The structure was solved by direct methods [2] and expanded using Fourier techniques. The non-hydrogen atoms were refined anisotropically. Hydrogen atoms were refined using the riding model. The final cycle of full-matrix least-squares refinement [3] on F2 was based on 3233 observed reflections and 199 variable parameters and converged (largest parameter shift was 0.00 times its esd) with unweighted and weighted agreement factors of:
References
Arnone A, et al. Secondary mould metabolites, LII. structure elucidation of diatretol – a new diketopiperazine metabolite from the fungus Clitocybe diatreta. Liebigs Ann. 1996;1996:1875–77.
Sheldrick GM. SHELXT version 2014/5. Acta Cryst. 2014;A70:C1437.
Least squares function minimized: (SHELXL version 2014/7) Sw(Fo2-Fc2)2 where w = least squares weights.
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Iijima, M., Masuda, T., Nakamura, H. et al. Correction to: Metacytofilin, a novel immunomodulator produced by Metarhizium sp. TA2759. J Antibiot 71, 908–909 (2018). https://doi.org/10.1038/s41429-018-0045-z
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DOI: https://doi.org/10.1038/s41429-018-0045-z
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