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Marine natural products targeting the eukaryotic cell membrane

The Journal of Antibiotics volume 74, pages 769–785 (2021)Cite this article

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Abstract

The cell membrane, with high fluidity and alternative curvatures, maintains the robust integrity to distinguish inner and outer space of cells or organelles. Lipids are the main components of the cell membrane, but their functions are largely unknown. Even the visualization of lipids is not straightforward since modification of lipids often hampers its correct physical properties. Many natural products target cell membranes, some of which are used as pharmaceuticals and/or research tools. They show specific recognition on lipids, and thus exhibit desired pharmacological effects and unique biological phenotypes. This review is a catalog of marine natural products that target eukaryotic cell membranes. Chemical structures, biological activities, and molecular mechanisms are summarized. I hope that this review will be helpful for readers to notice the potential of marine natural products in the exploration of the function of lipids and the druggability of eukaryotic cell membranes.

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Acknowledgements

I would like to thank Profs Minoru Yoshida (RIKEN; Univ. Tokyo) and Hideaki Kakeya (Kyoto Univ.). Research presented here was conducted in their laboratories with talented members. I especially thank Drs Yuko Arita, Ryosuke Sugiyama, Mr. Kohei Fujita, and Takahiro Nakatani. I am grateful to Profs Shigeki Matsunaga (Univ. Tokyo), Toshihide Kobayashi (CNRS), Nobuaki Matsumori (Kyushu Univ.), and Hendrik Luesch (Univ. Florida) for exciting collaborations, and Prof. William Fenical (UCSD) for his warm encouragement. I thank Mayuki Sasaki for reading this paper. Research presented here was supported in part by JSPS KAKENHI (18K06717, 17H06401, 16K13086, 25702048), Nagase Science and Technology Foundation, the Institute for Fermentation, Osaka (IFO), and Suntory Institute for Bioorganic Research.

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    Shinichi Nishimura

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Note: Shinichi Nishimura was awarded the Sumiki-Umezawa Memorial Award from the Japan Antibiotics Research Association in 2020. This review article is partly based on his award-winning research.

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Nishimura, S. Marine natural products targeting the eukaryotic cell membrane. J Antibiot 74, 769–785 (2021). https://doi.org/10.1038/s41429-021-00468-5

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