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A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B

The Journal of Antibiotics volume 75, pages 1–8 (2022)Cite this article

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Abstract

The ribosome-targeted antifungal agent hygromycin B (HygB) alters the secondary metabolite profiles of fungi. Hypoxylon truncatum NBRC 32353 fermented in the presence of hygromycin B in barley medium activated secondary metabolite synthesis. A new benzaldehyde derivative truncaaldehyde (1) was obtained, along with thirteen known compounds (2–14). The structures of the new compounds were revealed using NMR and single-crystal X-ray crystallography. The total synthesis of (±)-1 was achieved using a four-step sequence, and chiral separation was accomplished. The isolated compounds were tested for their monoamine oxidase (MAO) -A and -B inhibitory activities, with six compounds ((±)-1, 4, 5, 7, 8, and 10) showing inhibitory activity.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyaki-dai, Sakado, Saitama, 350-0295, Japan

    Hitoshi Kamauchi, Koichi Takao & Yoshiaki Sugita

  2. Department of Chemistry, Faculty of Science, Josai University, 1-1 Keyaki-dai, Sakado, Saitama, 350-0295, Japan

    Mitsuaki Suzuki

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  1. Hitoshi Kamauchi
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Correspondence to Hitoshi Kamauchi.

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Kamauchi, H., Suzuki, M., Takao, K. et al. A benzaldehyde derivative obtained from Hypoxylon truncatum NBRC 32353 treated with hygromycin B. J Antibiot 75, 1–8 (2022). https://doi.org/10.1038/s41429-021-00483-6

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