Abstract
Background
Overdiagnosis of papilloedema is common and carries significant potential for morbidity from over-investigation and over-treatment. We aimed to determine the community prevalence of false positive diagnosis of papilloedema (FPE) on fundus imaging.
Methods
We evaluated fundus images from a community cross-section of 198 12–14-year-olds from the Avon Longitudinal Study of Parents and Children (ALSPAC) longitudinal cohort study database and patient images from our hospital departmental database with and without papilloedema. We asked clinicians, in isolation, to rate the subjects as a forced choice task to “papilloedema” or “not papilloedema” based on the fundus images alone. Raters comprised (i) four neuro-ophthalmologists, (ii) four ophthalmologists, (iii) four neurologists and (iv) four emergency medicine physicians.
Results
The prevalence of FPE in the ALSPAC population, defined as images mistaken as papilloedema by χ% of raters (Pχ) varied from P100 = 0% to P50 = 21.3 ± 3.9%. In the hospital population, there was a lower rate of FPE, P50 = 7.1 ± 10.8%. Sensitivity for papilloedema detection approached 100%, though three raters incorrectly labelled the same patient with unilateral disc swelling as normal, all other cases were detected by all raters.
Conclusions
Fundus photography assessment in isolation is highly sensitive but poorly specific for papilloedema detection. Using this method to screen the general population has significant potential for harm as overdiagnosis occurs, even in the hands of experienced clinicians.
Similar content being viewed by others
Introduction
On 15 July 2016, Honey Rose, an optometrist in Suffolk, UK, was convicted of gross-negligence manslaughter for failing to detect 8-year-old Vincent Barker’s papilloedema in February 2012. Although she was subsequently cleared on appeal, the case has had a significant effect on UK optometric and ophthalmic practice [1,2,3]. In this case, Honey Rose conducted a routine sight-test examination of Vincent Barker, which involved direct ophthalmoscopy and fundus photography [1]. She reported that direct ophthalmoscopy was unsuccessful because of photophobia and fundus photographs demonstrating papilloedema were obtained, but Ms Rose accidentally viewed the wrong images, incorrectly concluding that the fundus appearance was normal [1]. Vincent Barker died 5 months later, in July 2012, from hydrocephalus [1].
Since the conviction of Honey Rose, neuro-imaging requests and outpatient referrals for papilloedema have increased [2, 3]. The Honey Rose case centred around the use of fundus photography for papilloedema detection. Fundus photography is routinely used in most UK optometric practices and has been advocated to improve posterior segment evaluation [4].
Because papilloedema may be the presenting feature of life-threatening conditions, its diagnosis often precipitates an urgent hospital admission, brain imaging and lumbar puncture [5]. However, it is often over-diagnosed putting patients through unnecessary treatment and invasive investigations [2, 6]. False positive diagnosis of papilloedema (FPE) may be caused by an anomalous optic disc appearance, termed pseudo-papilloedema [7], or misinterpretation of the fundus appearance.
Outpatient referrals of patients with suspected papilloedema are common in UK and USA, but few of these patients are diagnosed with papilloedema [2, 8], suggesting that the prevalence of FPE is much higher than that of papilloedema.
The prevalence of optic disc drusen (ODD), which are one of the causes of pseudo-papilloedema, was 0.035% in a clinical study and up to 2% in cadaveric studies [9, 10]. The prevalence of FPE on fundus photographic screening by a single neuro-ophthalmologist of a morbidly obese population undergoing bariatric surgery was up to 2% [11]. The prevalence of FPE in the general population and comparison of accuracy between different specialists has not previously been reported.
We aimed to investigate the prevalence of FPE on fundus images in a community sample of unselected children.
Methods
Ethical approval for the study was obtained from the Avon Longitudinal Study of Parents and Children (ALSPAC) Ethics and Law Committee. The study protocol was approved by the hospital trust Research and Development Department and conformed to the tenets of the Declaration of Helsinki.
Participants providing images
The ALSPAC is a longitudinal birth cohort study of children born to mothers resident in Avon, UK who had an estimated delivery date between April 1 1991 and December 31 1992, including ~72% of eligible pregnant women [12]. The ALSPAC study website contains details of all the data that is available through a fully searchable data dictionary at http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/. Informed consent was obtained from all subjects and parents/guardians. Subjects included were all aged between 11.8 and 14.2 years at the time of the study visit. For the purposes of this study, the ALSPAC cohort was assumed to be representative of the general population.
Patient images were obtained from the hospital eye department fundus photographic database.
Participant information
Cross-sectional data were collected from children at age 12–14 years. Demographic information collected included: age, gender, maternal-reported ethnicity socioeconomic status. Socio-economic status was categorised using the highest value for parental employment from both parents (Standard Occupational Classification). The study visit included: autorefraction using a Canon R50 autorefractor (Canon Medical Systems, Melville, NY); best corrected LogMAR visual acuity (BCVA), height, weight and body fat percentage. Height was measured with shoes and socks removed using a Harpenden stadiometer (Holtain Ltd, Crymych, Pembs, United Kingdom) to the nearest 0.1 cm, and weight was measured by using a Tanita TBF 305 body-fat analyzer and weighing scales (Tanita UK Ltd, Yewsley, Middlesex, United Kingdom). BMI was calculated as weight (kilograms)/height (metres squared). To screen for health problems, one year after the images were taken, parents and guardians were asked to report on the health of the subject over the previous year.
For hospital patients, clinical information, including the presence or absence of papilloedema, was derived from retrospective analysis of the electronic patient records and paper charts where necessary.
Gold standard determination of papilloedema vs. not papilloedema
Our main aim was to determine the prevalence of FPE. There is no gold standard test to exclude papilloedema, although options include fundus fluorescein angiography and lumbar puncture, both of which are invasive and would be unethical to perform in a large community sample such as the ALSPAC database.
In children, the main causes of papilloedema are intracranial mass lesions, which have an incidence of 2–4/100,000 and idiopathic intracranial hypertension, which is less frequent than the adult incidence of 0.9/100,000 [13, 14]. The probable number of participants with papilloedema in the ALSPAC cohort was close to zero (99% confidence interval 0.001–0.02 of 150 participants assuming a frequency of 4/100,000) and for confirmation of this, we reviewed the responses about the children’s health, given in parent-completed questionnaires sent out approximately a year after the children had their fundus photographs taken. We therefore assumed that all cases in which papilloedema was called in the ASPAC community sample were FPE.
Gold standard for the hospital patients was taken as clinical diagnosis.
Fundus images
ALSPAC images were 45° digital retinal images centred on the macula acquired using a Topcon nonmydriatic retinal camera (Topcon TRC-NW6s, Topcon Technologies, Paramus, NJ) fitted with a Nikon D1X camera (Nikon, Tokyo, Japan). Images were available for 3350 ALSPAC participants attending a multidisciplinary data collection session. All images were reviewed by two authors (RB and CW). Bilateral images from 150 patients were selected at random from the ALSPAC database. To assess intra-observer correlation, a random selection of 10 bilateral images were duplicated.
Patient fundus images were all acquired on a Topcon TRC-50DX (Type 1 A) Mydriatic Retinal Camera (with Nikon D300) after pharmacologic dilatation. Bilateral fundus images from 28 patients without papilloedema and 10 patients with papilloedema were randomly selected from the Eye Department fundus photographic database. Only images centred on the macula were included, so that they were in the same format as the ALSPAC images.
Images were excluded when the image quality was rated as inadequate to assess optic disc swelling by RJB and JH.
Assessment of fundus photographs
We conducted a prospective assessment in groups of four senior (UK Consultant level) physicians. The groups of physicians were: neuro-ophthalmologists (NO), ophthalmologists (O), neurologists (N) and emergency medicine physicians (EM). We presented ALSPAC and patient images together in a forced choice task where we required raters to assign fundus photos to papilloedema or not papilloedema groups, based on the photographic appearance alone. Physicians were not told the source of the images and were masked to any clinical details because they were only shown fundus images in isolation and in a random order with community and hospital images mixed together.
Sample size
Sample size was calculated as previously described for observational studies as \(\frac{{Z^2P(1 - P)}}{{d^2}}\) [15], where Z is normal statistic for the level of confidence (1.96 for 95%), d is the level of precision required (set to half the prevalence) and P is the expected prevalence (published FPE rates are 2–12.5% [11, 16]). To detect a 10% rate of FPE with 95% confidence, requires n = 138. A 5% rate of FPE requires n = 291. Preliminary discussions suggested that more than 200 images would deter clinicians from rating the images and we therefore elected to present 150 ALSPAC images.
Statistical analysis
Statistical analysis was performed in SPSS 21 (IBM Corp. Armonk, NY), except for free-marginal kappa which was calculated as previously described to assess inter-rater reliability (http://justusrandolph.net/kappa/) [17]. Intra-rater agreement was not assessed because only 10 images were repeated and none were identified as papilloedema. Unless otherwise specified, means are displayed ± standard error of the mean. Confidence intervals (CI) for proportions were calculated using normal approximation to the binomial distribution or the binomial distribution when the proportion mean and variance were greater than 10. Specificity (false positives compared to true negatives) was assessed by modelling the proportion of true negative responses in the ALSPAC community sample and hospital images without papilloedema using generalised estimating equations with a binomial model with logit identity function and an exchangeable correlation matrix [18]. Sensitivity (true positives compared to false negatives) was assessed by modelling the proportion of true positive responses in the hospital images with papilloedema, as for specificity. The relationship between patient factors and FPE was assessed by fitting a generalised linear model (negative binomial) with continuous measurements (body mass index [BMI], body fat percentage, gestational age at birth, birthweight, age, spherical equivalent and BCVA) as covariates and gender, ethnicity and maternal social class as factors.
Proportions were compared using Pearson’s χ2 test. The rate of FPE (P) is displayed as the proportion of patients who were mistaken as having papilloedema by χ% of raters (Pχ).
Results
Prevalence of FPE
The prevalence of FPE in the ALSPAC population, defined as patients who were mistaken as having papilloedema by χ% of raters (Pχ) varied with the value of χ (Fig. 1a). No patient was incorrectly assessed as papilloedema by all raters and only one by >90% of observers (P90 = 0.67; 95% CI 0–3.7%; Fig. 2a), whilst 32 patients were incorrectly assessed as papilloedema by 50% of observers (P50 = 21.3; 95% CI 14.8–27.9%), a proportion that was not significantly different between the NO, O and N groups.
In the hospital population, two patients were incorrectly assessed as papilloedema by >50%, giving a P50 of 7.1 (95% CI 0.9–23.5%; Fig. 1b).
Sensitivity and specificity papilloedema detection
Sensitivity for papilloedema detection approached 100%, although one ophthalmologist and two neurologists incorrectly labelled the same patient with unilateral disc swelling (Fig. 2b) as without papilloedema (sensitivities: NO, 100%; O, 98 ± 2.4%; N, 95 ± 4.7%; ED 100%).
Specificity for the assessment of papilloedema was lower, with individual specificities ranging from 42.7–100%, being lowest in the EM physicians (NO, 85 ± 2.0%; O, 90 ± 1.7%; N, 87 ± 2.1%; ED, 53 ± 3.6% p < 0.001). Specificity was lower for the ALSPAC than the hospital images (ALSPAC 75 ± 2.2%; hospital 87 ± 3.1%; p = 0.007).
Consistency of decision-making
Across all raters and images, there was 72.6% agreement, with a free-marginal kappa of 0.45 (95% CI 0.4–0.5), indicating a moderate overall consistency between raters. The free-marginal kappa was highest for neurologists (0.70 [95%CI 0.63–0.77]) and lowest for emergency medicine physicians (0.38 [95%CI 0.30–0.46]), with ophthalmologists (0.68 [95%CI 0.61–0.75]) and neuro-ophthalmologists (0.54 [95%CI 0.46–0.62]) falling in between.
The agreement of neuro-ophthalmologists and ophthalmologists were lowered by one clinician in each group with FPE rates of 0% and 0.5%, respectively.
ALSPAC population
At age 12–14, 3350 subjects had fundus images available, but these subjects did not differ in terms of visual acuity or refractive error from those who attended the study visit but had no available images (see Supplementary file, Table 1).
Compared to the 10,777 subjects in the ALSPAC cohort without available images (including clinic attenders and non-attenders), those with available photographs contained 3% more females (p = 0.003), 1% more white patients, 6% more subjects in social class 1 and 2 (higher socioeconomic status; p < 0.001) and 1% fewer premature children (p < 0.001; see Supplementary file, Table 2).
Patient factors affecting FPE
There was no evidence of a relationship between FPE and patient age (p = 0.180), gender (p = 0.582), ethnicity (p = 0.215), maternal social class (p = 0.824), BMI (p = 0.993), body fat percentage (p = 0.624), gestational age at birth (p = 0.548), mother’s age at birth (0.707), birth weight (p = 0.545), refraction (p = 0.212) or BCVA (p = 0.651; Fig. 3). All except one ALSPAC subject were reported as being healthy in the subsequent year after the images were taken and that one subject was judged to have papilloedema by one ED physician only.
Discussion
The P50 rate of FPE in our community-based sample was 21.3%, suggesting a very high potential for asymptomatic members of the general population to be referred for papilloedema investigations based on fundus photography screening alone.
Our sample size calculations suggested that our study had 95% power to detect an FPE rate greater than 10%, less than the 21.3% detected, suggesting that we were adequately powered to define this prevalence with a precision less than 5%.
The forced choice task in the absence of clinical information limits the generalisability of the results to experienced neuro-ophthalmologists, who are very likely to use additional information to aid their decision-making. However, the finding of apparent papilloedema on fundus examination should usually precipitate further investigation whether additional features are present or not. Less experienced and non-medical professionals may be less able to use additional clinical features from history and examination in their decision-making: thus, in the community or emergency department setting practitioners often face a forced choice of whether or not to refer.
Subtle papilloedema is difficult to distinguish from pseudo-papilloedema, and our data do not suggest a solution beyond the utility of a second opinion. Optical coherence tomography (OCT) currently has limited utility to differentiate, as increased retinal nerve fibre layer thickness has been reported in both papilloedema and pseudo-papilloedema [19, 20]. Fluorescein angiography is most sensitive, but is invasive and often not readily available in the community [21]. The clinician may also assess spontaneous venous pulsation (SVP) at the optic disc, which strongly suggests that papilloedema is absent but is unfortunately less common in eyes with anomalous optic discs [22]. The rate of FPE may be lower when patients are assessed on a slit lamp or with a direct ophthalmoscope, but this was not the case in the FOTO-ED studies, where clinical examination alone did not usually help distinguish FPE after fundus photographic screening by neuro-ophthalmologists [personal communication—Dr. Beau Bruce, Emory University, Atlanta, GA USA, 2018].
In our study, the detection of papilloedema by fundus photography was extremely sensitive, even among EM physicians, consistent with previous reports [16, 23,24,25]. That three raters missed the same case of asymmetric papilloedema suggests a need to highlight that papilloedema may be asymmetric [26]. The exponential reduction in FPE rates with a requirement for increasing agreement, suggests that second and third opinions from ophthalmology or neurology colleagues may help differentiate papilloedema from FPE.
In determining the sensitivity of papilloedema detection, taking the gold standard as clinical diagnosis in the hospital patients and questionnaire assessment plus assumed normality in the community sample limits generalisability, because one or two missed cases of papilloedema in the community or hospital samples would greatly reduce observed sensitivity. However, we did not design the study to assess the sensitivity of fundus photographic screening for ophthalmic pathology, which has been previously assessed in the FOTO-ED studies [16, 23,24,25], which found a FPE rate of 2–12.5% after EM physician review of fundus photography in patients for whom fundus examination was indicated and a sensitivity for papilloedema detection of 83% [16]. These studies did not systematically assess the rate of FPE in neuro-ophthalmologists’ image assessments, although this was very low [personal communication—Dr. Beau Bruce, Emory University, Atlanta, GA USA, 2018]. This difference from our study may reflect different context and approaches (FOTO-ED involved real clinical decisions) or that the FOTO-ED neuro-ophthalmologists would all have fallen towards the low-FPE end of our panel of raters.
The agreement among individual physicians on which patients had FPE was moderate to substantial (kappa 0.45–0.7), greater than a previous study, which found a kappa range 0.17–0.43 for non-fluorescein imaging modalities [21], suggesting common decision-making strategies. None of our 10 cases of papilloedema were mild (Frisén 1) in both eyes and we therefore cannot comment on the level of agreement between observers on subtle true disc swelling. However, all FPE cases appeared to be no more than subtle papilloedema, so the disagreement between observers was on what constituted subtle disc swelling.
The hospital population had a significantly lower FPE rate (and higher specificity of a papilloedema diagnosis) than our community-based sample, though at 7.1%, this still leaves a very high potential for the hospital population to be referred for papilloedema investigations. Possible explanations for this difference include that the community-based cohort were aged 12–14 years, whilst the hospital database included predominantly adults. However, there was no significant effect of age on FPE assessment in our data and in a recent study of methods to diagnose papilloedema, FPE was more common in patients under 12 years [21], suggesting that our cohort of patients over 12 years should not have an age-related increase in the FPE rate.
Our assumption that the ALSPAC subjects did not have papilloedema was based on the very low population rate (<0.01%) and the lack of reported health problems by the subjects’ parents and guardians one year later [13, 14]. There were no cases of frank papilloedema in the included cases or in any of the other 3350 images viewed by RB and CW whilst preparing the study and there was no relationship between FPE and other known associations with papilloedema such as BMI and body fat percentage, suggesting that this assumption was sound. Were this assumption violated, two cases of true papilloedema in the community sample would change the observed rate of FPE or specificity by only 1.3%.
The P50 rate of FPE was 21.3 ± 3.9% for the ALSPAC images and 7.1 ± 10.8% for the hospital images, suggesting that screening of the general population by fundus imaging has significant potential for harm in terms of over diagnosis of papilloedema with pressure on secondary care services and morbidity from investigations and great but unnecessary anxiety caused to patients and families. However, the high sensitivity for papilloedema detection in all groups including EM physicians supports its targeted use in patients for whom fundus examination is indicated to exclude papilloedema.
Summary
What was known before
Overdiagnosis of papilloedema is common and carries significant potential for morbidity from over-investigation and over-treatment. The community rate of false positive papilloedema on fundus examination is not known.
What this study adds
In a community sample of 12–14 year-olds, 21% had false positive diagnosis of papilloedema on fundus photography by half of all raters. For the hospital population in the eye clinic, this proportion was 7%.
References
White J. Criminal trial of optom. Optometry Today. 2016. https://www.aop.org.uk/ot/professional-support/clinical-and-regulatory/criminal-trial-of-optometrist-begins.
Dahlmann-Noor AH, Adams GW, Daniel MC, Davis A, Hancox J, Hingorani M, et al. Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study. Br J Ophthalmol. 2018;102:318–22.
Poostchi A, Awad M, Wilde C, Dineen RA, Gruener AM. Spike in neuroimaging requests following the conviction of the optometrist Honey Rose. Eye. 2017;32:489–90.
Dabasia PL, Edgar DF, Garway-Heath DF, Lawrenson JG. A survey of current and anticipated use of standard and specialist equipment by UK optometrists. Ophthalmic Physiol Opt. 2014;34:592–613.
Mollan SP, Markey KA, Benzimra JD, Jacks A, Matthews TD, Burdon MA, et al. A practical approach to, diagnosis, assessment and management of idiopathic intracranial hypertension. Pract Neurol. 2014;14:380–90.
Fisayo A, Bruce BB, Newman NJ, Biousse V. Overdiagnosis of idiopathic intracranial hypertension. Neurology. 2016;86:341–50.
Rosenberg MA, Savino PJ, Glaser JS. A clinical analysis of pseudopapilledema. I. Population, laterality, acuity, refractive error, ophthalmoscopic characteristics, and coincident disease. Arch Ophthalmol. 1979;97:65–70.
Kovarik JJ, Doshi PN, Collinge JE, Plager DA. Outcome of pediatric patients referred for papilledema. J AAPOS. 2015;19:344–8.
Friedman AH, Gartner S, Modi SS. Drusen of the optic disc. A retrospective study in cadaver eyes. Br J Ophthalmol. 1975;59:413–21.
Wilkins JM, Pomeranz HD. Visual manifestations of visible and buried optic disc drusen. J Neuroophthalmol. 2004;24:125–9.
Krispel CM, Keltner JL, Smith W, Chu DG, Ali MR. Undiagnosed papilledema in a morbidly obese patient population: a prospective study. J Neuroophthalmol. 2011;31:310–5.
Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, Henderson J, et al. Cohort Profile: the ‘children of the 90s’–the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol. 2013;42:111–27.
Kaatsch P, Rickert CH, Kuhl J, Schuz J, Michaelis J. Population-based epidemiologic data on brain tumors in German children. Cancer. 2001;92:3155–64.
Rigi M, Almarzouqi SJ, Morgan ML, Lee AG. Papilledema: epidemiology, etiology, and clinical management. Eye Brain. 2015;7:47–57.
Pourhoseingholi MA, Vahedi M, Rahimzadeh M. Sample size calculation in medical studies. Gastroenterol Hepatol Bed Bench. 2013;6:14–17.
Bruce BB, Thulasi P, Fraser CL, Keadey MT, Ward A, Heilpern KL, et al. Diagnostic accuracy and use of nonmydriatic ocular fundus photography by emergency physicians: phase II of the FOTO-ED study. Ann Emerg Med. 2013;62:28–33 e1.
Randolph JJ. Free-marginal multirater kappa (multirater K[free]): an alternative to Fleiss’ fixed-marginal multirater kappa. In: Paper Presented at the Joensuu Learning and Instruction Symposium, Joensuu, 14–15 October, 2005. https://files.eric.ed.gov/fulltext/ED490661.pdf.
Genders TS, Spronk S, Stijnen T, Steyerberg EW, Lesaffre E, Hunink MG. Methods for calculating sensitivity and specificity of clustered data: a tutorial. Radiology. 2012;265:910–6.
Bassi ST, Mohana KP. Optical coherence tomography in papilledema and pseudopapilledema with and without optic nerve head drusen. Indian J Ophthalmol. 2014;62:1146–51.
Fard MA, Fakhree S, Abdi P, Hassanpoor N, Subramanian PS. Quantification of peripapillary total retinal volume in pseudopapilledema and mild papilledema using spectral-domain optical coherence tomography. Am J Ophthalmol. 2014;158:136–43.
Chang MY, Velez FG, Demer JL, Bonelli L, Quiros PA, Arnold AC, et al. Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema. Ophthalmology. 2017;124:1839–48.
Hedges TR Jr, Baron EM, Hedges TR 3rd, Sinclair SH. The retinal venous pulse. Its relation to optic disc characteristics and choroidal pulse. Ophthalmology. 1994;101:542–7.
Bruce BB, Lamirel C, Biousse V, Ward A, Heilpern KL, Newman NJ, et al. Feasibility of nonmydriatic ocular fundus photography in the emergency department: Phase I of the FOTO-ED study. Acad Emerg Med. 2011;18:928–33.
Lamirel C, Bruce BB, Wright DW, Delaney KP, Newman NJ, Biousse V. Quality of nonmydriatic digital fundus photography obtained by nurse practitioners in the emergency department: the FOTO-ED study. Ophthalmology. 2012;119:617–24.
Lamirel C, Bruce BB, Wright DW, Newman NJ, Biousse V. Nonmydriatic digital ocular fundus photography on the iPhone 3G: the FOTO-ED study. Arch Ophthalmol. 2012;130:939–40.
Bidot S, Bruce BB, Saindane AM, Newman NJ, Biousse V. Asymmetric papilledema in idiopathic intracranial hypertension. J Neuroophthalmol. 2015;35:31–6.
Acknowledgements
We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses.
DOPS Study Group members
S.P. Mollan3,5, S.Y. Lo6, A.K. Denniston2,6, S. Dulku6
Funding
The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website. This study was supported in part by NIHR Doctoral (AC; DRF-2015-08-018) and Senior (CW; SRF-2015-08-005) Research Fellowships. Dr Creavin also works as part of the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is funded by the MRC grant code: MC_UU_12013/3.
Author information
Authors and Affiliations
Consortia
Contributions
RJB, JH, AC, MAB and WC planned the research. RB, JH, AC and WC conducted the research. RJB wrote the manuscript and JH, AC, DOPS study group members, MAB and WC revised the manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Members of the DOPS Study Group are listed below the Acknowledgements.
Supplementary information
Rights and permissions
About this article
Cite this article
Blanch, R.J., Horsburgh, J., Creavin, A. et al. Detection of Papilloedema Study (DOPS): rates of false positive papilloedema in the community. Eye 33, 1073–1080 (2019). https://doi.org/10.1038/s41433-019-0355-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41433-019-0355-9
This article is cited by
-
Papilloedema: a highly specific predictor of raised intracranial pressure in a complex neurosurgical paediatric cohort
Child's Nervous System (2024)
-
Prevalence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in suspected papilloedema in children
Eye (2023)
-
Impact of an email advice service on filtering and refining ophthalmology referrals in England
International Ophthalmology (2023)
-
Diagnostic Error in Neuro-ophthalmology: Avenues to Improve
Current Neurology and Neuroscience Reports (2022)
-
Reviewing the Recent Developments in Idiopathic Intracranial Hypertension
Ophthalmology and Therapy (2020)