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Socket outcomes following enucleation for uveal melanoma: post enucleation socket syndrome can be challenging

Eye volume 38, pages 192–197 (2024)Cite this article

Subjects

Abstract

Purpose

To evaluate socket outcomes of enucleation for uveal melanoma.

Methods

This study was a retrospective chart review conducted in December 2022 of all patients who underwent enucleation surgery for uveal melanoma between 2010 and 2015 in the Royal Victoria Eye and Ear Hospital, to evaluate socket outcomes including completion of revision surgery, type of surgery, and completion of multiple revision surgeries, and potential associations.

Results

Between June 2010 and December 2015, 72 patients underwent enucleation for uveal melanoma in the ocular oncology service, including 25 females and 47 males, mean age 65, range 11–91 years old. There were 68 primary enucleations and 4 secondary enucleations. Complete follow-up data was available for mean 4 years, range 1–11 years. Fourteen patients underwent further surgery, including one exenteration for local recurrence. Oculoplastic surgery (n = 6, 8%), implant exposure repair (n = 3, 6%), and orbit volume expanding surgery (n = 4, 6%) were also performed. Eight patients (11%) underwent one further surgery and five patients (7%) underwent a series of procedures. There was a significant association with younger age at enucleation (age <65) with undergoing further surgery (p = 0.03, Fisher’s Exact Test (FET)), and also an association of younger age with undergoing multiple further surgeries (p = 0.02, FET). There was no association found with other predictor variables, including primary versus secondary enucleation status. Most patients (75%) with PESS underwent more than one surgery.

Conclusion

Post enucleation surgery 82% of patients did not undergo further surgery, but younger patients were more likely to undergo anophthalmic socket revision or oculoplastic surgery. Management of post enucleation socket syndrome was challenging and usually involved a series of procedures.

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Fig. 1: Study inclusion flow diagram for revision surgery post enucleation for uveal melanoma.
Fig. 2: Post-enucleation indications for revision surgery and procedures performed.

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Data availability

The data supporting the findings of this study are found within the article and are not otherwise publicly archived.

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Authors and Affiliations

  1. Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, D02 XK51, Ireland

    Clare Quigley, Hanan Elshelmani, Gabrijela Fajin, Aisling McGlacken- Byrne, Clare McCloskey, Valerie O’Neill & Noel Horgan

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  1. Clare Quigley
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Contributions

CQ was responsible for the initial preparation of the manuscript, NH was responsible for supervision and study design. CQ, HE, GF AMB, CM and VON were involved in data collection. All co-authors were involved in development of the discussion provided critical revision of and feedback on the manuscript.

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Correspondence to Clare Quigley.

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Quigley, C., Elshelmani, H., Fajin, G. et al. Socket outcomes following enucleation for uveal melanoma: post enucleation socket syndrome can be challenging. Eye 38, 192–197 (2024). https://doi.org/10.1038/s41433-023-02657-y

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