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Optical coherence tomographic findings of glaucomatous eyes with papillomacular retinoschisis

Eye volume 38, pages 266–273 (2024)Cite this article

Subjects

Abstract

Objectives

To investigate the relationship between the shape of the optic nerve head (ONH) margin detected by optical coherence tomography (OCT) and the clinical characteristics of glaucomatous eyes with papillomacular retinoschisis (PMRS).

Methods

The medical record of patients with a PMRS in a glaucomatous eye were reviewed. The eyes were placed into two groups determined by the shape of the ONH margin in the OCT images; eyes with an externally oblique ONH margin (Group 1) and eyes with an internally oblique ONH margin (Group 2). We compared the clinical characteristics of the PMRS of these two groups.

Results

We studied 31 eyes of 29 patients with PMRS and glaucoma with 24 eyes in Group 1 and 7 eyes in Group 2. The optic nerve fibre layer schisis on the lamina cribrosa (LC), beta zone, and gamma zone, and found that the LC defects were detected significantly more frequently in Group 1 than in Group 2 eyes (P < 0.05). A retinal nerve fibre schisis was observed around the ONH significantly more frequently in Group 2 than in Group 1 eyes (P < 0.01).

Conclusion

The cases of glaucoma-associated PMRS could be classified into two groups according to the obliquity of the ONH. They had differences in the findings of OCT and FA. The possibility that the mechanism of PMRS development is different in both groups is suggested.

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Fig. 1: Representative Group 1 case with a papillomacular retinoschisis (PMRS).
Fig. 2: Representative case with PMRS in a Group 2 eye.
Fig. 3: Vitreous tractions in eyes with an externally and an internally oblique margin of the ONH.

Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author (TI) on reasonable request.

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Acknowledgements

The authors thank Professor Emeritus Duco Hamasaki of the Bascom Palmer Eye Institute, University of Miami, Miami, Florida, for the discussions and thorough editing of the manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Kyorin University, School of Medicine, Tokyo, Japan

    Tomoka Ishida, Yoshiyuki Kita, Yuji Itoh, Masaharu Mizuno, Kazunari Hirota, Takashi Koto, Makoto Inoue & Akito Hirakata

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  1. Tomoka Ishida
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Contributions

All authors declare they meet the current ICMJE criteria. TI, YK, MI, MM, KH, TK and MI collected data and analysed the ophthalmological findings. TI and YK analysed statistical findings. YI, YK and AH gave critical suggestions. TI, YK and AH prepared the manuscript. YI proofread the manuscript.

Corresponding author

Correspondence to Tomoka Ishida.

Ethics declarations

Competing interests

TI: Personal fees (lecture fees) from Nikon Co., Ltd., and Santen Pharmaceutical Co., Ltd., outside the submitted work. YK: Personal fees (lecture fees) from Santen Pharmaceutical Co., Ltd., and Senju Pharmaceutical Co., Ltd., Glaukos, outside the submitted work., YI None. MM: Personal fees (lecture fees) from Novartis Pharma K.K., Santen Pharmaceutical Co., Ltd., and KOWA Co., Ltd., outside the submitted work., KH: None, TK: Research grants from Ellex, and personal fees (lecture fees) from Alcon Laboratories, Inc., Novartis Pharma K.K., Bayer AG, Carl Zeiss Meditec AG, Novartis Pharma K.K., Santen Pharmaceutical Co., Ltd., HOYA Co., Ltd., Rohto Nitten Co., Ltd., River field Co., Ltd., and Senju Pharmaceutical Co., Ltd., AMO., outside the submitted work. MI: Research grants from Alcon Laboratories, Inc., Santen Pharmaceutical Co., Ltd., and personal fees (lecture fees) from Alcon Laboratories, Inc., Novartis Pharma K.K., Bayer AG, Carl Zeiss Meditec AG, Novartis Pharma K.K., HOYA Co., Ltd., Chugai Pharmaceutical Co., Ltd., Santen Pharmaceutical Co., Ltd., and Senju Pharmaceutical Co., Ltd., AMO Japan Co., Ltd., Logic and design Co., Ltd.,, outside the submitted work. AH: Research grants from Santen Pharmaceutical Co., Ltd., and personal fees (lecture fees) from Santen Pharmaceutical Co., Ltd., Alcon Laboratories, Inc., Novartis Pharma K.K., Bayer AG, Carl Zeiss Meditec AG, Novartis Pharma K.K., Sanwa Kagaku Kenkyusho Co., Ltd and., Senju Pharmaceutical Co., Ltd., HOYA Co., Ltd., outside the submitted work. Institutional Review Board Statement: This study was approved by the Institutional Review Committee of the Kyorin University School of Medicine (approval number #1627). Informed Consent Statement: The patients received a detailed explanation of the surgical and ophthalmic procedures, and all signed an informed consent form. The patients consented to our review of their medical records and their anonymized use in medical publications. The patient consent for this study was obtained in an opt-out format.

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Ishida, T., Kita, Y., Itoh, Y. et al. Optical coherence tomographic findings of glaucomatous eyes with papillomacular retinoschisis. Eye 38, 266–273 (2024). https://doi.org/10.1038/s41433-023-02671-0

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