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Gender differences in central serous chorioretinopathy based on the new multimodal imaging classification

Eye volume 38, pages 964–967 (2024)Cite this article

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Abstract

Purpose

To analyse the gender-specific differences in central serous chorioretinopathy (CSCR) based on a new multimodal imaging classification system.

Method

This was a retrospective, multicentric, longitudinal, observational study in patients with a diagnosis of unilateral or bilateral CSCR. Visual acuity outcomes and differences based on ‘Simple’ and ‘Complex’ CSCR were analysed. The occurrence of choroidal neovascularization (CNVM) and number of recurrences were also compared. Regression analysis was used to evaluate baseline predictors of final visual acuity.

Results

The study included 109 eyes of 58 patients (55 eyes of 28 female patients and 54 eyes of 30 male patients). Simple CSCR was seen in 8 (14.8%) eyes and 21 (38.2%) eyes in male and female groups respectively, while complex CSCR was seen in 46 (85.2%) eyes and 34 (61.8%) eyes in male and female groups respectively (p = 0.005). Recurrence was more commonly seen in males (34 eyes) than in females (23 eyes) (p = 0.03). Males (96.7%) were also significantly more likely to have a bilateral presentation (78.6% in females) (p = 0.03). Conversely, CNVM was more commonly seen in female eyes (8 eyes) than male eyes (4 eyes) (p = 0.23). On multivariable regression analysis, factors affecting reduced need for treatment were history of steroid use, good visual acuity at baseline, and simple CSCR. Factors affecting good final visual acuity were history of steroid use, good visual acuity at baseline, and younger age.

Conclusion

Males tended to have complex CSCR and recurrence compared to the female sub-group, while females exhibited CNVM more commonly than males.

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Fig. 1: Example of simple and complex CSCR.

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Data availability

The data that support the findings of this study are available from the corresponding author, JC, upon reasonable request.

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Authors and Affiliations

  1. Anant Bajaj retina Institute, Kode Venkatadri Chowdary Campus, L V Prasad Eye Institute, Vijayawada, India

    Niroj Kumar Sahoo & Ashwini Kulkarni

  2. UPMC Eye Centre, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Joshua Ong, Amrish Selvam, Richard Brown & Jay Chhablani

  3. Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Milana Avdalimov & Dinah Zur

  4. Anant Bajaj retina Institute, Kallam Anji Reddy campus, L V Prasad Eye Institute, Hyderabad, India

    Saarang Hansraj

  5. Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA

    Ramkailash Gujar

  6. Department of Medicine and Surgery, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy

    Ramkailash Gujar & Marco Lupidi

Authors
  1. Niroj Kumar Sahoo
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  2. Joshua Ong
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  4. Richard Brown
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  9. Marco Lupidi
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  10. Dinah Zur
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  11. Jay Chhablani
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Contributions

JC: design. JO, AS, AK, SH, RG: Conduct of the study. NKS, MA, RG, AK, SH: Collection. MA, ML, DZ, JC: Management. NKS, JO, AS, RB: Analysis. NKS, JO: Interpretation of the data. NKS, JO, RB: Preparation. RB, ML, DZ, JC: Review. ML, DZ, JC: approval of the manuscript.

Corresponding author

Correspondence to Jay Chhablani.

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Sahoo, N.K., Ong, J., Selvam, A. et al. Gender differences in central serous chorioretinopathy based on the new multimodal imaging classification. Eye 38, 964–967 (2024). https://doi.org/10.1038/s41433-023-02812-5

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