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Tessellated fundus occurs earlier than myopia in children aged 3–6 years

Eye (2024)Cite this article

Subjects

Abstract

Background/Objectives

Tessellated fundus can exist in normal healthy eyes. This study aims to evaluate the occurrence and influencing factors of tessellated fundus in preschool children aged 3–6 years.

Subjects/Methods

This kindergarten-based cross-sectional study included 1716 children with an age range of 3–6 years. All participants underwent a comprehensive eye examination and a questionnaire. According to the number of quadrants occupied by tessellated fundus around the optic disc in fundus photographs, it was divided into four grades.

Results

600 (35.0%) children had peripapillary tessellation. According to the spherical equivalent (SE), the subjects were divided into three groups: Hyperopia group (SE > + 0.75D, n = 1194)；Pre-myopia group (−0.50D < SE ≤ + 0.75D, n = 455); Myopia group (SE ≤ −0.50D, n = 67). The proportion of peripapillary tessellated fundus was 33.0%, 38.0%, 50.7% respectively. According to the regression analysis, in the non-myopia group (Pre-myopia group and Hyperopia group), the occurrence of peripapillary tessellated fundus was associated with longer axial length (OR, 1.566; 95% CI: 1.229–1.996, p < 0.001) and larger corneal radius of curvature (OR, 1.837; 95% CI: 1.006–3.354, p = 0.048). However, in Pre-myopia group, the corneal radius of curvature was not associated with the occurrence of peripapillary tessellated fundus (p = 0.830). In Hyperopia group, the corneal radius of curvature was associated with the occurrence of peripapillary tessellated fundus (OR, 2.438; 95% CI: 1.160–5.122, p = 0.019).

Conclusions

The occurrence of peripapillary tessellated fundus is more than 30% in 3–6 year old preschool children. Tessellated fundus can also occur in non-myopic children, and is related to the length of axial length and large radius of corneal curvature.

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Fig. 1: Different grades around the optic disc (grade 1–4).
Fig. 2: Proportion of tessellation in groups by SE.

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Data availability

Data will be available upon reasonable request to the corresponding author.

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Acknowledgements

The authors thank Professor Yaxing Wang for critical discussions and revision of the manuscript.

Funding

The Beijing Hyperopia Reserve Research was supported by the “Capital Clinical Diagnosis and Treatment Technology Research and Translational Medicine Application” of Beijing Municipal Science and Technology Commission (2020–2024, project number Z201100005520034).

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Authors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, 100730, Beijing, China

    Xuejing Mi, Yuxin Fang, Ranran Zhang, Dan Wang, Yanyan Yang, Chuzhi Peng, Shimeng Bian, Huaying Xu & Yonghong Jiao

  2. Maternal and Child Health Hospital of Haidian District, Beijing, China

    Jianing Pu & Wei Chen

  3. School of Biomedical Engineering, Capital Medical University, Beijing, China

    Zhen Zhou

  4. School of Geosciences and Surveying Engineering, China University of Mining and Technology-Beijing, 100083, Beijing, China

    Mengmeng Qin

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  1. Xuejing Mi
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Contributions

XM wrote the manuscript. YJ and YF supervised the study and edited the manuscript. XM, JP, WC, RZ, DW, YY, CP, SB and HX helped to collect data. Statistical analysis support was provided by ZZ. MQ provided support in figure processing. All authors read and approved the final manuscript.

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Correspondence to Yonghong Jiao.

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Mi, X., Fang, Y., Pu, J. et al. Tessellated fundus occurs earlier than myopia in children aged 3–6 years. Eye (2024). https://doi.org/10.1038/s41433-024-03036-x

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