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Increased late-onset glaucoma risk following vitrectomy for macular pucker or hole

Eye (2024)Cite this article

Subjects

Abstract

Objectives

The long-term risk of developing glaucoma after vitrectomy remains uncertain. This retrospective population-based cohort study aimed to explore this risk following vitrectomy for macular pucker or hole.

Methods

Utilizing Taiwan’s National Health Insurance Research Database (NHIRD), we included patients who were older than 18 years and had undergone vitrectomy surgery between 2011 and 2019. Exclusions were made for patients with prior diagnoses of glaucoma, congenital or secondary glaucoma, as well as those who had received previous vitreoretinal treatments or had undergone multiple vitrectomies.

Results

After an average follow-up period of 51 and 53 months respectively for the vitrectomized and non-vitrectomized group, our results showed a relative risk of 1.71 for glaucoma development in the vitrectomized group. Higher adjusted hazard ratios were also observed for open-angle glaucoma and normal tension glaucoma. Increased risks were associated with male sex, obstructive sleep apnoea, and migraine. In the subgroup analysis, phakic eyes at baseline and those who had undergone cataract surgery post-vitrectomy were associated with a lower risk of glaucoma development during follow-up. Among all glaucoma events, pseudophakic status at baseline had the shortest interval to glaucoma development following vitrectomy.

Conclusions

These findings underscore the potential relationship between vitrectomy and glaucoma onset, emphasizing the need for vigilant monitoring and early detection of glaucoma in post-vitrectomy patients.

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Fig. 1: Flowchart of the inclusion and exclusion of the participants.
Fig. 2: Cumulative incidence of glaucoma of the participants.

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Data availability

Due to NHIRD’s personal data protection regulations, the data from this study is not publicly accessible. Access is restricted to authorized individuals who have received approval from the Taiwan NHI bureau for data management purposes.

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Funding

The study was funded by Chang Gung Memorial Hospital (CMRPG3N1001, CGRPG3M0031, SMRPG3K0021 and XMRPG3M0041), Chang Gung Medical Foundation(CMRPD3L0022、CMRPD3L0021), the Ministry of Science and Technology, Taiwan (108-2410-H-182-008-MY2 and 110-2410-H-182-013-MY3), and the Wang Jhan-Yang Public Trust Fund (WJY 2020-HR-01, WJY 2021-HR-01, WJY 2022-HR-01, WYJ 2021-AP-01 and WYJ 2022-AP-01).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, 333, Taiwan

    Yung-Sung Lee, Tsung-En Huang, Chu-Yen Huang, Yih-Shiou Hwang, Wei-Chi Wu & Eugene Yu-Chuan Kang

  2. College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan

    Yung-Sung Lee, Tsung-En Huang, Chu-Yen Huang, Yih-Shiou Hwang, Wei-Chi Wu & Eugene Yu-Chuan Kang

  3. Laboratory for Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan, 333, Taiwan

    Yu-Chi Chen & Kuang-Hung Hsu

  4. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan

    Eugene Yu-Chuan Kang

  5. Department of Health Care Management, Healthy Aging Research Center, Chang Gung University, Taoyuan, 333, Taiwan

    Kuang-Hung Hsu

  6. Department of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan

    Kuang-Hung Hsu

  7. Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan

    Kuang-Hung Hsu

  8. Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan

    Kuang-Hung Hsu

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  1. Yung-Sung Lee
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Contributions

YSL and EYCK designed the study. YSL and EYCK drafted the manuscript. TEH, CYH, and KHH revised the manuscript. YCC, YSH, and WCW obtained the data. YSL, YCC, EYCK, WCW, and KHH interpreted the data. YSH and KHH conducted the critical review. EYCK and KHH supervised the study. All authors have read and approved the final manuscript.

Corresponding authors

Correspondence to Eugene Yu-Chuan Kang or Kuang-Hung Hsu.

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Cite this article

Lee, YS., Chen, YC., Huang, TE. et al. Increased late-onset glaucoma risk following vitrectomy for macular pucker or hole. Eye (2024). https://doi.org/10.1038/s41433-024-03096-z

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