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The relationship between day-to-day variability in home blood pressure measurement and multiple organ function

Hypertension Research volume 45, pages 474–482 (2022)Cite this article

A Comment to this article was published on 27 December 2021

Abstract

Blood pressure variability (BPV) is associated with the prognosis of cardiovascular diseases. However, it is unclear how BPV is related to various organs. The aim of this study is to investigate the association between BPV and multiple organ functions. A total of three hundred fifteen participants (114 males; mean age: 70 ± 9 years) participated in a community health checkup held in Tarumizu City. Home blood pressure (BP) was measured using a HEM-9700T (OMRON Healthcare, Kyoto, Japan). Day-to-day BPV was evaluated by the coefficient of variation (CV) of home BP measured in the morning for one month. N-terminal pro B-type natriuretic peptide (NT-pro BNP) and high-sensitivity (hs-)troponin T were measured as cardiac biomarkers. Liver stiffness and renal function were evaluated using the Fibrous-4 (Fib4) index and estimated glomerular filtration rate (eGFR), respectively. NT-pro BNP and hs-troponin T were divided by the median value. Fib4 index greater than 2.67 and eGFR less than 60 mL/min/1.73 m2 were defined as high Fib4 index and low eGFR, respectively. In a multivariable logistic regression analysis, the CV of systolic BP was significantly associated with high NT-pro BNP, high Fib 4 index, and low eGFR, but not with high hs-troponin T. In contrast, the CV of diastolic BP was not associated with low eGFR, and the other three biomarkers had the same results as systolic BP. In conclusion, day-to-day BPV of systolic BP is independently associated with NT-pro BNP, eGFR, and Fib4 index, but not with hs-troponin T. In contrast, diastolic BPV was not found to be associated with eGFR.

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Acknowledgements

We wish to thank Chikashi Yamaguchi and Kohko Horinouchi of the MeRAS Corporation for their help in obtaining BP data measured by the participants. This study was conducted by OMRON HEALTHCARE Co. Ltd. in cooperation with the Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University. The running cost of this observational study was funded by OMRON Healthcare Co., Ltd.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

    Takuro Kubozono, Yuichi Akasaki, Shin Kawasoe, Satoko Ojima, Takeko Kawabata, Yoshiyuki Ikeda & Mitsuru Ohishi

  2. Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    Hyuma Makizako

  3. Tarumizu Municipal Medical Center, Tarumizu Chuo Hospital, Kagoshima, Japan

    So Kuwahata & Toshihiro Takenaka

  4. Tarumizu City Office, Kagoshima, Japan

    Mayuka Maeda

  5. OMRON Healthcare Corporation, Kyoto, Japan

    Seisuke Fujiwara & Ken Miyagawa

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  1. Takuro Kubozono
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Correspondence to Takuro Kubozono.

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TK, AY, and MO received research support from Omron Healthcare Co., Ltd. MK, SF, and KM are employees of OMRON Healthcare Co., Ltd.

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Kubozono, T., Akasaki, Y., Kawasoe, S. et al. The relationship between day-to-day variability in home blood pressure measurement and multiple organ function. Hypertens Res 45, 474–482 (2022). https://doi.org/10.1038/s41440-021-00818-8

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