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Special Issue: Current evidence and perspectives for hypertension management in Asia

A multicenter prospective study of home blood pressure measurement (HBPM) during pregnancy in Japanese women

Hypertension Research volume 45, pages 1563–1574 (2022)Cite this article

Abstract

In the near future, hypertensive disorders of pregnancy (HDP) have been diagnosed by home blood pressure monitoring (HBPM) instead of clinic BP monitoring. A multicenter study of HBPM was performed in pregnant Japanese women in the non-high risk group for HDP. Participants were women (n = 218), uncomplicated pregnancy who self-measured and recorded their HBP daily. Twelve women developed HDP. HBP was appropriate (100 mmHg in systole and 63 mmHg in diastole), bottoming out at 17 to 21 weeks of gestation. It increased after 24 weeks of gestation and returned to non-pregnant levels by 4 weeks of postpartum. The upper limit of normal HBP was defined as the mean value +3 SD for systolic and mean +2 SD for diastolic with reference to the criteria for non-pregnant women. Using the polynomial equation, the hypertensive cut-off of systolic HBP was 125 mmHg at 15 weeks and 132 mmHg at 30 weeks of gestation, while it for diastolic HBP was 79 mmHg at 15 weeks and 81 mmHg at 30 weeks of gestation. Systolic HBP in women who developed HDP was higher after 24 weeks of gestation, and diastolic HBP was higher during most of the pregnancy compared to normal pregnancy. When the variability of individual HBP in women developed HDP compared to normal pregnant women was examined using the coefficient of variation (CV), the CV was lower in HDP before the onset of HDP. HBPM can be used not only for HDP determination, but also for early detection of HDP.

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Acknowledgements

The authors would like to thank the following collaborators: Gen Ishikawa, Masahiro Ohashi, Mitsumasa Shimazu, Takuya Saitoh, Chiharu Fukue, Ai Iwasaki, Kenji Yamaguchi, Koji Kanda, Keisuke Fukui, and Hiroki Suzuki.

Funding

This work was supported by Intramural Research Fund (28-4-2) for Cardiovascular Disease of the National Cerebral and Cardiovascular Center and by the 2015 JSSHP Foundation.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Fukiage Maternity Clinic, Nagoya, Japan

    Yoshikatsu Suzuki & Tamao Yamamoto

  2. Department of Obstetrics and Gynecology, Ehime University School of Medicine, Toon, Japan

    Keiichi Matsubara

  3. Department of Obstetrics and Gynecology, Perinatal and Neonatal Medical Center, Aichi Medical University School of Medicine, Nagakute, Japan

    Kazushi Watanabe

  4. Perinatal Medical Center, Hirosaki University Hospital, Hirosaki, Japan

    Kanji Tanaka

  5. Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan

    Tomoyoshi Nohira

  6. Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan

    Kazuya Mimura

  7. Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Shimotuke, Japan

    Hirotada Suzuki

  8. Department of Perinatology and Gynecology, Kochi Prefectural Hata Kenmin Hospital, Sukumo, Japan

    Fumiaki Hamada

  9. Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan

    Shintarou Makino

  10. Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan

    Keiko Koide

  11. Department of Obstetrics and Gynecology, Fujita Health University, Toyoake, Japan

    Haruki Nishizawa

  12. Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan

    Katsuhiko Naruse

  13. Department of Obstetrics and Gynecology, Saitama Medical University, Kawagoe, Japan

    Yukiko Mikami

  14. Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan

    Ikuno Kawabata

  15. Department of Obstetrics and Gynecology, National Cerebral and Cardiovascular Center, Suita, Japan

    Jun Yoshimatsu

  16. Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Nagakute, Japan

    Kohta Suzuki

  17. Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan

    Shigeru Saito

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Correspondence to Yoshikatsu Suzuki.

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Suzuki, Y., Matsubara, K., Watanabe, K. et al. A multicenter prospective study of home blood pressure measurement (HBPM) during pregnancy in Japanese women. Hypertens Res 45, 1563–1574 (2022). https://doi.org/10.1038/s41440-022-00992-3

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