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High-normal diastolic blood pressure as a risk factor for left ventricular diastolic dysfunction in healthy postmenopausal women

Hypertension Research volume 45, pages 1891–1898 (2022)Cite this article

A Comment to this article was published on 28 November 2022

Abstract

Left ventricular (LV) diastolic dysfunction is associated with heart failure with preserved ejection fraction, and metabolic syndrome (MetS) is a risk factor. However, there is limited knowledge regarding the metabolic factors that contribute to LV dysfunction in postmenopausal women without comorbidities. This study aimed to analyze the relationship between LV diastolic dysfunction and MetS, as well as other cardiovascular risk factors, and to determine risks for LV diastolic dysfunction. Postmenopausal women without hypertension, diabetes mellitus, LV systolic dysfunction, or other heart diseases underwent physical examinations, including echocardiography. The study participants were diagnosed with LV diastolic dysfunction based on several echocardiographic parameters. Logistic regression analyses of LV diastolic dysfunction and cardiovascular risk factors were performed. Of the 269 postmenopausal women examined, 29 (10.7%) and 40 (14.9%) had MetS and LV diastolic dysfunction, respectively. Abnormal diastolic blood pressure (odds ratio, 3.6; 95% confidence interval, 1.16–10.9; P < 0.05) and age (odds ratio, 1.1; 95% confidence interval, 1.07–1.19; P < 0.01) were predictors of LV diastolic dysfunction. In healthy postmenopausal women, high-normal diastolic blood pressure was the only independent risk factor for LV diastolic dysfunction, and it thus may be a useful predictor of diastolic heart failure during routine physical examinations.

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Acknowledgements

We thank Nature Research Editing Service for English language editing and publication support.

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Authors and Affiliations

  1. Institute of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan

    Makiko Kimura, Haruki Sekiguchi, Ken Shimamoto, Masatoshi Kawana, Nobuhisa Hagiwara & Junich Yamaguchi

  2. National Hospital Organization Yokohama Medical Centre, Yokohama, Kanagawa, Japan

    Haruki Sekiguchi

  3. National Hospital Organization Kyoto Medical Centre, Kyoto, Japan

    Haruki Sekiguchi

  4. Institute of General Medicine, Tokyo Women’s Medical University, Tokyo, Japan

    Haruki Sekiguchi, Ken Shimamoto, Masatoshi Kawana & Yousuke Takemura

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  1. Makiko Kimura
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  4. Masatoshi Kawana
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  5. Yousuke Takemura
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  6. Nobuhisa Hagiwara
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  7. Junich Yamaguchi
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Contributions

Conceptualization: KS and MK; writing—original draft preparation: MK and NH; writing—review and editing: MK, TY, NH, and JY. All authors have read and agreed to the version of the manuscript to be published.

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Correspondence to Haruki Sekiguchi.

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The authors declare no competing interests.

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The study was conducted in accordance withthe Declaration of Helsinki and approved by the Human Research Protection Office ofTokyo Women’s Medical University (protocol code #2507, approved June 25, 2012).

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Informed consent was obtained from all individuals involved in the study.

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Kimura, M., Sekiguchi, H., Shimamoto, K. et al. High-normal diastolic blood pressure as a risk factor for left ventricular diastolic dysfunction in healthy postmenopausal women. Hypertens Res 45, 1891–1898 (2022). https://doi.org/10.1038/s41440-022-01024-w

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  • DOI: https://doi.org/10.1038/s41440-022-01024-w

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