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  • Review Article
  • Special Issue: Current evidence and perspectives for hypertension management in Asia
  • Published:

Cognitive impairment in heart failure patients: association with abnormal circadian blood pressure rhythm: a review from the HOPE Asia Network

Hypertension Research volume 47, pages 261–270 (2024)Cite this article

Abstract

Cognitive impairment (CI) is frequently a comorbid condition in heart failure (HF) patients, and is associated with increased cardiovascular events and death. Numerous factors contribute to CI in HF patients. Decreased cerebral blood flow, inflammation, and activation of neurohumoral factors are all thought to be factors that exacerbate CI. Hypoperfusion of the brain due to decreased systemic blood flow, cerebral venous congestion, and atherosclerosis are the main mechanism of CI in HF patients. Abnormal circadian BP rhythm is one of the other conditions associated with CI. The conditions in which BP does not decrease sufficiently or increases during the night are called non-dipper or riser BP patterns. Abnormal circadian BP rhythm worsens CI in HF patients through cerebral congestion during sleep and atherosclerosis due to pressure overload. Interventions for CI in HF patients include treatment for HF itself using cardiovascular drugs, and treatment for fluid retention, one of the causes of abnormal circadian rhythms.

Proposed pathways of cognitive impairment in heart failure through abnormal circadian blood pressure rhythm.

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Acknowledgements

This work was supported by Japan Society for the Promotion of Science KAKENHI grant no. 16K19318. The authors thank Viatris for the grant to support the HOPE Asia Network activities.

HOPE Asia Network

Kazuomi Kario1, Ji-Guang Wang5, Yook-Chin Chia6,7, Peera Buranakitjaroen8, Chen-Huan Chen9, Hao-Min Cheng10,11,12,13, Satoshi Hoshide1 Takeshi Fujiwara1, Yan Li14, Minh Van Huynh15, Michiaki Nagai16, Jennifer Nailes17, Sungha Park18, Markus Schlaich19, Jinho Shin20, Saulat Siddique21, Jorge Sison22, Arieska Ann Soenarta23, Guru Prasad Sogunuru3,4, Apichard Sukonthasarn24, Jam Chin Tay25, Boon Wee Teo26, Kelvin Tsoi27, Yuda Turana28, Narsingh Verma29, Tzung-Dau Wang30,31, Yuqing Zhang32

Funding

Japan Society for the Promotion of Science KAKENHI grant no. 16K19318.

Author information

Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan

    Takahiro Komori, Satoshi Hoshide, Kazuomi Kario & Takeshi Fujiwara

  2. Department of Neurology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

    Yuda Turana

  3. Fortis Hospitals, Chennai, Tamil Nadu, India

    Guru Prasad Sogunuru

  4. College of Medical Sciences, Kathmandu University, Bharatpur, Nepal

    Guru Prasad Sogunuru

  5. Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Ji-Guang Wang

  6. Department of Medical Sciences, School of Medical Sciences and Life Sciences, Sunway University, Bandar Sunway, Selangor Darul Ehsan, Malaysia

    Yook-Chin Chia

  7. Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Yook-Chin Chia

  8. Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Peera Buranakitjaroen

  9. Department of Internal Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan

    Chen-Huan Chen

  10. Institute of Public Health and Community Medicine Research Center, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan

    Hao-Min Cheng

  11. Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Hao-Min Cheng

  12. Ph.D. Program of Interdisciplinary Medicine (PIM), National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan

    Hao-Min Cheng

  13. Division of Faculty Development, Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan

    Hao-Min Cheng

  14. Centre for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluations, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Yan Li

  15. Department of Internal Medicine, University of Medicine and Pharmacy, Hue University, Hue City, Vietnam

    Minh Van Huynh

  16. Department of Internal Medicine, General Medicine and Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan

    Michiaki Nagai

  17. Department of Preventive and Community Medicine and Research Institute for Health Sciences, University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines

    Jennifer Nailes

  18. Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea

    Sungha Park

  19. Dobney Hypertension Centre, Medical School- Royal Perth Hospital Unit and Royal Perth Hospital Research Foundation, The University of Western Australia, Perth, WA, Australia

    Markus Schlaich

  20. Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea

    Jinho Shin

  21. Punjab Medical Center, Lahore, Pakistan

    Saulat Siddique

  22. Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines

    Jorge Sison

  23. Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia

    Arieska Ann Soenarta

  24. Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Apichard Sukonthasarn

  25. Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore

    Jam Chin Tay

  26. Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore

    Boon Wee Teo

  27. JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong

    Kelvin Tsoi

  28. Department of Neurology. School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

    Yuda Turana

  29. Department of Physiology, King George’s Medical University, Lucknow, India

    Narsingh Verma

  30. Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan

    Tzung-Dau Wang

  31. Division of Hospital Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan

    Tzung-Dau Wang

  32. Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yuqing Zhang

Authors
  1. Takahiro Komori
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  2. Satoshi Hoshide
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  3. Yuda Turana
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  4. Guru Prasad Sogunuru
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  5. Kazuomi Kario
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Consortia

HOPE Asia Network

  • Kazuomi Kario
  • , Ji-Guang Wang
  • , Yook-Chin Chia
  • , Peera Buranakitjaroen
  • , Chen-Huan Chen
  • , Hao-Min Cheng
  • , Satoshi Hoshide
  • , Takeshi Fujiwara
  • , Yan Li
  • , Minh Van Huynh
  • , Michiaki Nagai
  • , Jennifer Nailes
  • , Sungha Park
  • , Markus Schlaich
  • , Jinho Shin
  • , Saulat Siddique
  • , Jorge Sison
  • , Arieska Ann Soenarta
  • , Guru Prasad Sogunuru
  • , Apichard Sukonthasarn
  • , Jam Chin Tay
  • , Boon Wee Teo
  • , Kelvin Tsoi
  • , Yuda Turana
  • , Narsingh Verma
  • , Tzung-Dau Wang
  •  & Yuqing Zhang

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Correspondence to Kazuomi Kario.

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KK reports research funding from Omron Healthcare, Fukuda Denshi; lecture fees from Viatris, Otsuka Pharmaceuticals, Daiichi Sankyo, Novartis Pharma, A&D, and Omron Healthcare; scholarship from Otsuka Pharmaceuticals, Daiichi Sankyo, Sumitomo Pharma, Boehringer Ingelheim Japan, Takeda Pharmaceuticals outside the submitted work. All other authors report no potential conflicts of interest in relation to this article.

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Komori, T., Hoshide, S., Turana, Y. et al. Cognitive impairment in heart failure patients: association with abnormal circadian blood pressure rhythm: a review from the HOPE Asia Network. Hypertens Res 47, 261–270 (2024). https://doi.org/10.1038/s41440-023-01423-7

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