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The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study

Hypertension Research volume 47, pages 672–676 (2024)Cite this article

A Comment to this article was published on 09 February 2024

Abstract

This cross-sectional study investigated the association between the estimated glomerular filtration rate (eGFR), a measure of chronic kidney disease (CKD), and cognitive impairment. We used data from 6215 Japanese individuals registered in the Suita Study. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score of ≤ 26. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) of cognitive impairment for eGFR 45–59.9 and < 45 mL/min/1.73 m2 (mild and moderate-to-severe eGFR reductions) compared to eGFR ≥ 60 mL/min/1.73 m2 (normal eGFR). The results showed that both mild and moderate-to-severe eGFR reductions were associated with cognitive impairment: ORs (95% CIs) = 1.49 (1.22–1.83) and 2.35 (1.69–3.26), respectively (p-trend < 0.001). Each increment of eGFR by 10 mL/min/1.73m2 was associated with 4.8% lower odds of cognitive impairment. In conclusion, eGFR reduction was associated with cognitive impairment. Managing CKD is essential for preventing cognitive impairment.

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Acknowledgements

We would like to thank the Suita Medical Association, the Suita City Health Center Staff, and all cohort members.

Funding

Funding

This study was supported by the Intramural Research Fund for the cardiovascular diseases of the National Cerebral and Cardiovascular Center (20-4-9), the JH Young Researcher Grant, the Health and Labour Sciences Research Grants of the Ministry of Health, Labour, and Welfare of Japan, AMED (21dk0207053h0001), and the Japan Science and Technology Agency (JPMJPF2018).

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Authors and Affiliations

  1. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan

    Ahmed Arafa, Haruna Kawachi, Chisa Matsumoto, Masayuki Teramoto, Yuka Yasui, Yuka Kato, Yoko M. Nakao, Rena Kashima & Yoshihiro Kokubo

  2. Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

    Ahmed Arafa

  3. Department of Environmental Medicine and Population Sciences, Graduate School of Medicine, Osaka University, Suita, Japan

    Haruna Kawachi

  4. Department of Cardiology, Center for Health Surveillance and Preventive Medicine, Tokyo Medical University Hospital, Shinjuku, Japan

    Chisa Matsumoto

  5. Graduate School of Human Life and Science, Doshisha Women’s College of Liberal Arts, Kyoto, Japan

    Yuka Yasui

  6. Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Japan

    Yuka Kato

  7. Department of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Japan

    Miki Matsuo

  8. Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan

    Yoko M. Nakao

Authors
  1. Ahmed Arafa
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  2. Haruna Kawachi
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  6. Yuka Kato
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  7. Miki Matsuo
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  8. Yoko M. Nakao
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  9. Rena Kashima
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  10. Yoshihiro Kokubo
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Contributions

AA drafted the manuscript. AA, HK, CM, MT, YY, YK, MM, YN, RK, and YK were involved in the study design, statistical analysis, revision, and editing.

Corresponding author

Correspondence to Ahmed Arafa.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

The Suita Study protocol was approved by the Institutional Review Board of the National Cerebral and Cardiovascular Center (R21024). We conducted the study per the Declaration of Helsinki. All participants signed their informed consent forms.

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Arafa, A., Kawachi, H., Matsumoto, C. et al. The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study. Hypertens Res 47, 672–676 (2024). https://doi.org/10.1038/s41440-023-01476-8

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