Humanized versions of antibodies with enhanced stability can be designed via the systematic energy-based ranking of computationally grafted non-human complementarity-determining regions onto thousands of human frameworks.
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Hummer, A.M., Deane, C.M. Designing stable humanized antibodies. Nat. Biomed. Eng 8, 3–4 (2024). https://doi.org/10.1038/s41551-023-01168-1
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DOI: https://doi.org/10.1038/s41551-023-01168-1