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Cargo recognition and degradation by selective autophagy

Nature Cell Biology volume 20, pages 233–242 (2018)Cite this article

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An Author Correction to this article was published on 07 June 2023

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Abstract

Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field.

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Fig. 1: The Cvt pathway, aggrephagy and pexophagy.
Fig. 2: Mitophagy, reticulophagy and nucleophagy.
Fig. 3: Lysophagy and xenophagy.

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Acknowledgements

This work was supported by NIH grant GM053396 to D.J.K.

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  1. Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

    Damián Gatica, Vikramjit Lahiri & Daniel J. Klionsky

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Gatica, D., Lahiri, V. & Klionsky, D.J. Cargo recognition and degradation by selective autophagy. Nat Cell Biol 20, 233–242 (2018). https://doi.org/10.1038/s41556-018-0037-z

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