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Size matters in nanoscale communication

Nature Cell Biology volume 20, pages 228–230 (2018)Cite this article

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Exosomes are heterogeneous, nanoscale vesicles that mediate cellular communication. A study now leverages a size separation strategy to identify sub-classes of nanoparticles, revealing a subtype without an encapsulating membrane and variation in vesicle cargo, suggesting that size is not the only driver of heterogeneity.

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Fig. 1: Schematic representation of vesicle subpopulations that comprise the cellular communication milieu.

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Authors and Affiliations

  1. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Andries Zijlstra

  2. Program in Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA

    Andries Zijlstra

  3. Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Dolores Di Vizio

  4. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Dolores Di Vizio

  5. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Dolores Di Vizio

Authors
  1. Andries Zijlstra
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  2. Dolores Di Vizio
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Correspondence to Dolores Di Vizio.

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Zijlstra, A., Di Vizio, D. Size matters in nanoscale communication. Nat Cell Biol 20, 228–230 (2018). https://doi.org/10.1038/s41556-018-0049-8

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