Multiple clones of cancer cells co-exist within a tumour, and yet it is not clear when these subclones arise and how they contribute to tumour progression. A multicolour clonal tracing study now shows that benign skin tumours are mostly monoclonal while the more advanced lesions are composed of multiple intermixed subclones.
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References
Fearon, E. R. & Vogelstein, B. Cell 61, 759–767 (1990).
McGranahan, N. & Swanton, C. Cell 168, 613–628 (2017).
Marusyk, A., Almendro, V. & Polyak, K. Nat. Rev. Cancer 12, 323–334 (2012).
Blundell, J. R. & Levy, S. F. Genomics 104, 417–430 (2014).
Reeves, M. Q., Kandyba, E., Harris, S., Del Rosario, R. & Balmain, A. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0109-0 (2018).
Snippert, H. J. et al. Cell 143, 134–144 (2010).
Wong, C. E. et al. Genes Dev. 27, 670–682 (2013).
Rappaport, A. & Johnson, L. Cold Spring Harb. Protoc. 2014, 897–911 (2014).
Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Nature 322, 78–80 (1986).
McCreery, M. Q. et al. Nat. Med. 21, 1514–1520 (2015).
Stransky, N. et al. Science 333, 1157–1160 (2011).
Martincorena, I. et al. Science 348, 880–886 (2015).
Muller, M. J., Neugeboren, B. I., Nelson, D. R. & Murray, A. W. Proc. Natl Acad. Sci. USA 111, 1037–1042 (2014).
Hoadley, K. A. et al. PLoS Med. 13, e1002174 (2016).
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Janiszewska, M., Polyak, K. A confetti trail of tumour evolution. Nat Cell Biol 20, 639–641 (2018). https://doi.org/10.1038/s41556-018-0110-7
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DOI: https://doi.org/10.1038/s41556-018-0110-7
