Phase separation can build assemblies and regulate biological function. Two articles link specific forms of protein and RNA degradation to phase separation. The polyubiquitin shuttle factor UBQLN2 localizes to stress granules where it may extract ubiquitinated proteins, and the miRISC complex functions through phase separation.
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Mittag, T., Fawzi, N.L. Protein quality and miRNA slicing get into phase. Nat Cell Biol 20, 635–637 (2018). https://doi.org/10.1038/s41556-018-0113-4
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DOI: https://doi.org/10.1038/s41556-018-0113-4
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